IndraLab

Statements

AGT increases the amount of SERPINE1. 97 / 97
2 | 92 3
reach
"Adenovirus mediated overexpression of clusterin inhibits Ang II stimulated expression of PAI-1, type I collagen, fibronectin and p-Smad3."
25148511
reach
"Consistent with earlier studies showing that Ang II can activate the MR, XREF_BIBR, XREF_BIBR spironolactone attenuated Ang II stimulated PAI-1 expression suggesting that Ang II increases PAI-1 expression through an MR dependent mechanism in VSMCs."
19225557
bel
"angiotensin II enhances production of IL6 and MCP1 by activation of NFKB in VSMC, and may also alter the fibrinolytic balance by augmenting plasminogen activator inhibitor - 1 expression (90, 91)"
16293001
sparser
"In HO-1 KO mice, AngII strongly induced PAI expression, and overall, the animals with aneurysm had a lower level of PAI (plasminogen activator inhibitor, xref C)."
33467682
reach
"These observations indicate that the coupling of AT1 receptors with IP hydrolysis and PKC activation may be important for Ang II stimulation of PAI-1 gene expression."
1537291
reach
"19 Angiotensin II supplementation increases PAI-1 mRNA levels in vitro 6,7 and in vivo."
11832778
reach
"In the present study, we demonstrate that the inhibition of PI3K in VSMCs by expression of a dominant negative p85alpha mutant lacking the p110 binding domain (Deltap85), or by treatment of cells with LY294002, inhibited Ang II stimulated PAI-1 (plasminogen activator inhibitor-1) mRNA expression."
16569213
reach
"Because the expression of TF and PAI-1 mRNA induced by Ang II was attenuated by the increase of intracellular concentrations of cAMP by forskolin and 8-bromo-cAMP and because AM increased the intracellular level of cAMP in rat aortic endothelial cells, it was indicated that the inhibitory effect of AM on the expressions of TF and PAI-1 was mainly mediated by the cAMP dependent signal transduction."
11397723
reach
"Further, Ang II increased phospho-c-Raf (Ser338), phospho-Erk1/2, and PAI-1 expression significantly more in the EC-PKCbeta2Tg mice compared with WT mice with Ang II (by 1.3 +/- 0.1-, 1.4 +/- 0.1-, and 1.5 +/- 0.2-fold, respectively)."
22826029
reach
"In addition, thrombotic events are observed, since AngII promotes the expression of plasminogen activator inhibitor-1 (PAI-1) and tissue-factors (TFs) [72,73]."
33265982
reach
"The membrane-permeant cGMP analogue 8-Br-cGMP reduced Ang II stimulated PAI-1 expression by 60%, and an inhibitor of soluble guanylyl cyclase (1H-[1,2,4] oxadiazolo [4, 3-a] quinoxalin-1-one) significantly impaired the inhibitory effects of S-nitroso-N-acetylpenicillamine on Ang II stimulated PAI-1 expression."
9812917
reach
"Mast cell derived exosomes contain TNF-alpha, angiotensinogen, factor V and prothrombin, which all induce the expression of plasminogen activator inhibitor type 1 (PAI-1) in endothelial cells, causing procoagulant activity and endothelial dysfunction."
29922170
reach
"Ang II significantly induced cardiac fibrosis [increased collagen accumulation and CTGF expression], inflammation (elevated TNF-alpha and PAI-1 expression, Fig. 5 C), and oxidative damage [increased a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29353218
reach
"In vitro and vivo studies have shown that Ang II stimulates the expression and release of PAI-1."
32607467
reach
"Angiotensin II stimulates PAI-1 expression in adipocytes and ramipril, an angiotensin converting enzyme (ACE) inhibitor has been shown to lower PAI-1 in patients with acute MI [XREF_BIBR]."
21707474
reach
"Ang II stimulated PAI-1 expression in the heart, aorta, and kidney and markedly in the liver of WT mice."
17429342
reach
"PAI-1 expression and protein secretion induced by Ang II in 4G/4G HUVEC was completely inhibited by preincubation with 0.05 microM losartan (p < 0.01), indicating an AT1 mediated effect."
15194475
reach
"In endothelial cells from control mice (WT; C57Bl6/J), both AngII and AngIV treatments increased PAI-1 mRNA expression in a dose dependent manner, whereas the response was blunted in endothelial cells from IRAP (-/-) mice."
19745198
reach
"The data presented here indicate that Ang II treatment of mesangial cells in culture markedly increases PAI-1 gene transcription and PAI-1 mRNA levels but does not change the half life of PAI-1 mRNA."
9067897
reach
"This study shows that high glucose and Ang II stimulate PAI-1 expression through AP-1 binding sites."
11440364
reach
"Considering that AngII stimulates PAI-1 expression, these observations may explain, at least in part, the difference that we observed between both drugs regarding liver PAI-1 expression."
19230890
reach
"Angiotensin II induces PAI-1 expression through MAP kinase dependent, but TGF beta and PI3 kinase independent pathway."
11250428
reach
"Ghrelin ameliorated AngII induced renal tubular cell senescent changes and AngII induced TGF-beta and PAI-1 expressions."
24747517
reach
"Angiotensin II stimulation of plasminogen activator inhibitor-1 gene expression in astroglial cells from the brain."
1537291
reach
"Interestingly, Ang II stimulated THP-1-derived exosomes also enhanced the expression of ICAM1 and PAI-1 and contained reduced levels of miR-17 compared with exosomes from unstimulated cells."
27881852
reach
"When dealing with the expression of PAI, Feener et al. [16] found that in rat microvessel endothelial cells PAI-1 and PAI-2 expression are AT1-R dependent, whereas Vaughan et al. [17] reported that PA[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9065746
reach
"Ang II induced upregulation of PAI-1 mRNA expression was prevented by a protein kinase C (PKC) inhibitor, bisindorylmaleimide I."
10209301
reach
"Our results indicate that Ang II activates PAI-1 gene expression through the AT1 receptor and involves the calcium dependent activation of calcineurin and the nuclear translocation of NFAT."
11983698
reach
"It should be emphasised that AngII and aldosterone increase the expression of PAI-1, a major inhibitor of fibrinolysis in vivo, in vascular smooth muscle and endothelial cells [14]."
35407377
reach
"Angiotensin II (or IV) has been reported to stimulate the expression of plasminogen activator inhibitor-1 (PAl-1) in cultured endothelial cells [26,27]."
10454299
reach
"In accordance with the results of Northern blot analysis, Ang II and TGF-beta induced PAI-1 protein expression, and a synergistic effect of Ang II and TGF-beta was observed by the Western blot analysi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10209301
reach
"In rats, overexpression of clusterin by intrarenal delivery attenuated Ang II stimulated expression of PAI-1, matrix proteins, and AT1R."
25148511
bel
"Systemic infusion of angiotensin II results in an increase in plasminogen activator inhibitor type 1 (PAI-1) levels "
20470281
reach
"Angiotensin IV stimulates plasminogen activator inhibitor-1 expression in proximal tubular epithelial cells."
10432384
reach
"Further, D-Sp1-ODN (-85 to -63) containing the GT box attenuated up-regulation of PAI-1 mRNA expression induced by Ang II to a level (68 +/-9% inhibition) comparable to D-P-ODN, whereas ODN with four mutations in the GT box had no effect."
10880342
reach
"Ang II significantly increased mRNA expression of plasminogen activator inhibitor-1 (Pai 1) within cardiac, renal, and aortic tissue (XREF_FIG)."
22622494
reach
"We further confirmed that Ang II increased PAI-1 expression in differentiated mature adipocytes."
22648117
reach
"We conclude that AT1a receptor mediated Ang II signaling modulates the circadian expression of PAI-1 in an organ specific manner."
15835378
reach
"ANG II induced a transient induction of junB and a delayed induction of PAI-1 and OPN mRNA levels, which were reduced by ERK inhibition with U-0126."
18156195
reach
"Angiotensin II (Ang II) increases levels of aldosterone and plasminogen activator inhibitor-1 (PAI-1)."
14581407
reach
"In RGECs, Ang II significantly increased phospho-c-Raf (Ser338), phospho-Erk1/2, and PAI-1 expression by 9.9 +/- 2.4-, 9.2 +/- 2.2-, and 2.2 +/- 0.6-fold, respectively."
22826029
reach
"AngII and aldosterone can also induce PAI-1 expression and subsequent fibrosis independent of TGF-beta activation [XREF_BIBR]."
17647026
reach
"Furthermore, Ang II dose-dependently inhibited adipogenesis of MSCs mainly through the AT2 receptor and upregulated PAI-1 expression in differentiated adipocytes."
22648117
reach
"Although PAI-1 gene expression was also stimulated by Ang II in neuronal cultures of SH rat brain, two differences between WKY and SH rat brain neurons were observed : 1) the level of Ang II stimulation in SH rat neurons was 50% of that in WKY rat neurons; and 2) Ang II stimulation of c-fos was 2.4-fold higher in SH neurons than in WKY neurons, but c-fos antisense oligonucleotide did not attenuate the stimulatory action of Ang II on PAI-1 mRNA in SH neurons."
8641204
reach
"Ang II increased PAI-1 and TF mRNA expression without affecting that of TPA or TFPI."
9241756
reach
"As a result, AM inhibited Ang II induced TF and PAI-1 mRNA expression in a dose- and time dependent manner."
11397723
reach
"The expression of the PAI-1 gene is directly induced by Ang II [15], however, little is known about the molecular events through which Ang II induces PAI-1 gene expression in mesangial cells."
10209301
reach
"Signalling through angiotensin II type 1 and angiotensin IV receptors upregulates expression of PAI-1 148."
26592189
sparser
"Apelin protects against cardiac fibrosis and vascular remodeling through blocking Ang II-induced PAI-1 gene expression and increasing NO production [ xref ]."
| PMC
sparser
"The apelins-12 and -13 inhibit the vasoconstrictive effect of Ang-II and confers beneficial cardiovascular effects through ACE2/Ang(1-7)-and/or Larginine/endothelial nitric oxide synthase (eNOS)/nitric oxide (NO)-dependent and vascular remodeling through blocking Ang II-induced PAI-1 gene expression and increasing NO production [16]."
| PMC
reach
"We have recently shown that Ang II is able to induce PAI-1 expression and release via the AT1-receptor in human fat cells in primary culture, and have provided the first evidence that two metabolites, Ang III and Ang IV, may have a similar stimulatory effect on PAI-1 release."
11383921
reach
"In contrast, amastatin was not able to prevent the expression of PAI-1 mRNA induced by Ang IV."
10432384
reach
"In situ hybridization and immunostaining showed low expression of PAI-1 mRNA and protein in tubular epithelium in beta6 (-/-) UUO kidneys, with increased PAI-1 expression in response to Ang II, Aldo, or both."
14507636
reach
"Ang II also stimulates the expression of PAI-1 messenger RNA (mRNA) in endothelial cells and increases plasma PAI-1 levels in a dose dependent manner."
32607467
reach
"Angiotensin II (also produced by adipose tissue) is a biologically active angiotensinogen processing agent and has been shown to stimulate PAI-1 expression at the transcriptional level in human adipocytes [XREF_BIBR]."
33804680
reach
"In contrast, Ang II did not elevate PAI-1 mRNA levels in astroglial cultures from neonatal rat brains."
1537291
reach
"These cells respond to the local renal renin-angiotensin system and secrete increased amounts of PAI-1 and IL-6 in response to Ang II."
19501024
reach
"However, by 24 h the enhanced PAI-1 expression reverts nearly to baseline levels even though Ang II produces sustained upregulation of PAI-1 expression (XREF_FIG)."
20471392
reach
"It has been shown that Ang II modulates fibrinolysis, that is, Ang II increases plasminogen activator inhibitor-1 (PAI-1) mRNA and plasma PAI-1 levels in vitro and in vivo."
9409318
reach
"In the present study, we demonstrate that brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) interact with angiotensin II (Ang II) in regulative blood coagulation and fibrinolysis by suppressing the expressions of both tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) induced by Ang II."
10595644
reach
"Ang II also enhanced plasminogen activator inhibitor-1 expression, which inhibits metalloproteinases that degrade the extracellular matrix."
10715259
reach
"Induction of PAI-1 mRNA expression by Ang II was not inhibited by pretreating BAECs with either Dup 753 or [Sar1, Ile8]-Ang II, agents that are known to compete effectively for binding to the two major angiotensin receptor subtypes."
7884001
reach
"Ang IV stimulated PAI-1 mRNA expression, whereas it did not induce a significant increase in tritiated thymidine uptake after 24 hours of incubation."
10432384
reach
"As shown in Fig. 2, 0.03 nM GLP-1 significantly inhibited Ang II induced up-regulation of mRNA levels of ICAM-1 and PAI-1 in mesangial cells, which were blocked by the treatment with H-89."
22750392
reach
"Our results demonstrate that Ang II stimulates PAI-1 mRNA expression and the production of its protein in human proximal tubular cells."
10432384
reach
"Ang II induces PAI-1 expression at the transcriptional level [15]."
10209301
reach
"In advanced atherosclerotic lesions, Ang II stimulates matrix metalloproteinases (MMPs) and plasminogen activator inhibitor-1 expression, causing destabilization of atherosclerotic plaque and alteration of fibrinolytic balance [XREF_BIBR - XREF_BIBR]."
21234405
reach
"For instance, Ang IV increased the expression of plasminogen activator inhibitor-1 (PAI-1) mRNA in bovine endothelial cells, suggesting a role for the peptide in fibrinolytic balance [26]."
10498341
reach
"Ang II alone increased PAI-1 expression."
19225557
reach
"Angiotensin II and IV stimulate expression and release of plasminogen activator inhibitor-1 in cultured human coronary artery endothelial cells."
12021572
reach
"Angiotensin II (AG II) has an adipogenic effect and increases PAI-1 expression."
16413628
reach
"Immunoblotting for phosphorylated myosin phosphatase subunit and myosin light chain revealed that apelin blocked Ang II activation of the Rho kinase pathway, which is associated with induction of PAI-1 gene expression by Ang II."
21358420
reach
"In both WT and EC-PKCbeta2Tg mice, treatment with exendin-4 increased phospho-c-Raf (Ser259) and significantly decreased Ang II induced phospho-c-Raf (Ser338), phospho-Erk1/2, and PAI-1 expression."
22826029
reach
"The increase in PAI-1 expression by high glucose and Ang II was significantly attenuated by the AP-1 decoy ODN (p < 0.05 or p < 0.01)."
11440364
reach
"We conclude that Ang II stimulates PAI-1 expression in part through the AT (1b) receptor in the kidney and liver."
17429342
reach
"Angiotensin-II induction of plasminogen activator inhibitor-1 gene expression in astroglial cells of normotensive and spontaneously hypertensive rat brain."
1491687
reach
"For example, activation of angiotensin-1 type-4 receptors, bradykinin type-2 and endothelin-1 A receptors have all been linked to the increased expression and elevated plasma levels of PAI-1 elicited by AngII, and the same receptors have been implicated in AngII mediated arteriolar thrombosis [XREF_BIBR, XREF_BIBR], suggesting a cause-effect relationship between the elevated PAI-1 level and accelerated arteriolar thrombosis."
24495184
reach
"Angiotensin II, very low density lipoproteins, and unsaturated fatty acids induce the expression of PAI-1 whereas estrogen suppresses synthesis of PAI-1 [XREF_BIBR - XREF_BIBR]."
18615155
reach
"Consistently, ICG-001 also abolished Ang II induced cardiac fibronectin, collagen I and PAI-1 protein expression."
29895976
reach
"In vitro and vivo studies have shown that Ang II stimulates the expression and release of PAI-1."
32607467
reach
"Ang II increased mRNA and protein levels of TGF-beta1, FN, TIMP-1, and PAI-1 in a time- and dose dependent manner in RPMCs."
20662702
reach
"A decrease in Ang-II activity, NO, cGMP, prostaglandin E2, and prostacyclin causes anti-cancerous effects intensified by an ACEI mediated decreased in the PAI level and the inhibition of metalloproteinase activity."
29098020
reach
"Both angiotensin II (Ang II) and angiotensin IV (Ang IV) have been reported to stimulate PAI-1 expression."
17444273
reach
"Lastly, Ang II increased mRNA levels of PAI-1 by 5.4 +/- 2.4-fold, which was also inhibited by GFX and RBX by 45 +/- 21 and 36 +/- 15%, respectively."
22826029
reach
"It is noted that AngII and aldosterone increase the expression of PAI-1, a major inhibitor of fibrinolysis in vivo, in vascular smooth muscle and endothelial cells XREF_BIBR."
| PMC
reach
"However, infusion of Ang II in beta6 -/- UUO mice markedly increased PAI-1 expression to a pattern similar to that seen in WT, with increased proximal tubule PAI-1 expression."
14507636
reach
"Ang II did not only significantly induce PARP-1 expression and activity, but also increased PAI-1 and FN expression in RMCs."
21613793
reach
"This study tested the hypothesis that hyperglycaemia and Ang II stimulate PAI-1 gene expression through activator protein-1 (AP-1) binding sites."
11440364
reach
"It has recently been reported that Ang II stimulates the expression of plasminogen activator inhibitor-1 (PAI-1) in several cell lines."
10432384
reach
"In contrast, AON to mitogen activated protein kinase failed to inhibit Ang II stimulation of plasminogen activator inhibitor-1 mRNA levels."
8753867
reach
"Recent studies from this laboratory have demonstrated that angiotensin II (Ang II) stimulates the expression of plasminogen activator inhibitor 1 (PAI-1) in cultured endothelial cells."
7593643
reach
"Ang II stimulated the expression of hypoxia inducible factor-1alpha at both mRNA and protein levels, and also enhanced the expression of plasminogen activator inhibitor-1 (PAI-1)."
18048061
reach
"Ang II also stimulates the expression of PAI-1 messenger RNA (mRNA) in endothelial cells and increases plasma PAI-1 levels in a dose-dependent manner."
32607467
reach
"Ang II increased aortic mRNA expression of PAI-1, collagen I, collagen III, fibronectin, osteopontin, monocyte chemoattractant protein-1, and F4/80; PAI-039 significantly decreased the Ang II induced increase in aortic osteopontin expression at 8 weeks."
15576638
reach
"Spironolactone (10 -6 M) prevented Ang II stimulated PAI-1 mRNA expression and attenuated the effect of Ang II + aldosterone on PAI-1 expression such that the PAI-1 mRNA expression was similar to that after treatment with aldosterone alone but still increased compared with control."
19225557
reach
"In neonatal rat cardiomyocytes, Ang II increased PAI-1 mRNA expression by 4-fold (P < 0.01), and this response was completely blocked by AT (1) receptor antagonism."
11031218
reach
"This study aimed to identify the intracellular signaling pathway in angiotensin II (Ang II)-induced upregulation of plasminogen activator inhibitor type 1 (PAI-1) mRNA expression in cultured rat glomerular mesangial cells, and to examine the interaction between Ang II and TGF-beta signaling."
10209301