IndraLab

Statements

USP30 inhibits autophagy of mitochondrion. 12 / 12
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"USP30 negatively regulates mitophagy and promotes myocardial cell senescence through antagonism on Parkin."
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"In particular, pharmacological inhibition of USP30 induces a significant increase in cardiac mitophagy without detriment to cardiac function."
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"In cultured cells, including neurons, USP30 overexpression inhibits mitophagy, and this effect is not seen when a catalytically inactive mutant of USP30 is employed ."
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"It is well established that the USP30 dependent suppression of mitophagy may rely on over-expressed Parkin together with an overt depolarization ."
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"Current models invoke USP30 functioning under normal physiological conditions to prevent inappropriate mitophagy."
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"Deubiquitinating enzyme USP30 negatively regulates mitophagy and accelerates myocardial cell senescence through antagonism of Parkin."
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"Overall, our results demonstrate the pharmacological inhibition of USP30 by ST-539 modulates PINK1/Parkin dependent mitophagy, and efficiently induces cardiac mitophagy."
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"Pharmacological Inhibition of USP30 activates Tissue-specific Mitophagy."
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"Depletion of USP30 has been shown to promote mitochondrial elongation and mitophagy (Nakamura & Hirose, 2008)."
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"Furthermore, the knockdown of USP30 enhances mitophagy in cultured cells ."
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"The E3 ligase Parkin ubiquitinates the membrane proteins on targeted mitochondria to initiate mitophagy, whereas USP30 antagonizes Parkin-dependent mitophagy by removing ubiquitin from Parkin substrates."
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"Much less understood are the inhibitors of USP30 and whether inhibiting USP30 will activate mitophagy in vivo."
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