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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

KLF6 inhibits TNFAIP3. 1 / 1

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"As shown in XREF_FIG, NFKBIA knockdown completely or partially rescued KLF6-wt effect on the majority of the tested genes; furthermore, although not always statistically significant, it seemed to prevent KLF6 mediated upregulation of the other NF-kappaB-negative regulators (TNIP1, TNIP2 and TNFAIP3, XREF_SUPPLEMENTARY), suggesting that NF-kappaB could mediate a positive feedback loop by downregulating its negative regulators as previously described."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...