IndraLab

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Slob activates KCNMA1. 7 / 7
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"SLOB protein is thought to bind the SLO and EAG potassium channels, and can directly enhance SLO activity, as well as mediate the inhibitory effect of 14-3-3zeta on SLO [XREF_BIBR, XREF_BIBR]."
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"SLOB binds to and modulates SLO activity in mNSCs XREF_BIBR; in addition, we recently demonstrated that flies lacking SLOB exhibit enhanced neurotransmission at the neuromuscular junction, and this is due to modulation of SLO by SLOB in the presynaptic nerve terminal XREF_BIBR."
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"Taken together, these results suggest that modulation of SLO by SLOB mediates the effects of SLOB on metabolism and gene expression."
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"In order to determine if the effects of SLOB on gene expression and metabolism are dependent on modulation of SLO by SLOB, we crossed the mutant slo 1 line XREF_BIBR into the WT P41 and slob IP1 fly lines to generate WT P41, slo 1 and slob IP1, slo 1 lines."
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"We propose that modulation of SLO by SLOB regulates neurotransmission in mNSCs, influencing downstream insulin pathway signaling and metabolism."
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"Importantly, intact SLO function is necessary for changes manifested in the slob null phenotype, implying that the modulation of SLO by SLOB mediates the alterations in gene expression and metabolism."
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"SLOB expression level in these neurons modulates whole-cell potassium current and properties of single SLO channels XREF_BIBR."
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