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"These results cumulatively indicate that tea polyphenol pretreatment could suppress the TLR4 and NF-kappaB p65 signaling pathway, protecting renal tubular epithelial cells against ischemia and reperfusion induced apoptosis, which implies that antioxidants may be a potential and effective agent for prevention of the ischemic and reperfusion injury through the suppression extrinsic apoptotic signal pathway induced by TLR4 and NF-kappaB p65 signal pathway."