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KCNH1 activates cell population proliferation. 58 / 64
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"In these cell lines, eag1 enhances the proliferation of the cells XREF_BIBR, and is required for the maintenance of growth."
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"The inhibition of Eag1 channels reduced cancer cell proliferation and also inhibited tumor growth in vivo [67]."
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"Eag1 Blockage Reduces the Proliferation of Liposarcoma Cells."
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"The precise mechanism how K V 10.1 promotes proliferation of cancer cells is still under debate, although it is known that it includes both permeation dependent and -independent components."
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"It has been proposed recently that perinuclear localization of Eag1 could lead to the activation of MAPK pathway, resulting in increased cell proliferation [XREF_BIBR]."
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"In this study, we verified that EAG1 promotes the proliferation of hepatocellular carcinoma (HCC) both in vitro and in vivo."
33097858
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"Eag1 Silencing Reduces the Proliferation of Osteosarcoma Cells."
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"The suppression of Eag1 expression caused a significant reduction of cancer cell proliferation XREF_BIBR - XREF_BIBR."
23569431
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"Finally, siRNA mediated knockdown of Eag1 expression reduces proliferation, and the inhibition of channel function reduces tumor progression both in vitro and in vivo."
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"Based on the findings in previous studies that potassium voltage gated channel subfamily H member 1 (KCNH1) was overexpressed in osteosarcoma and promoted the proliferation and invasion of osteosarcoma [XREF_BIBR - XREF_BIBR] and on our profile of the miRanda, PITA, RNAhybrid databases to explore the corresponding circRNAs of KCNH1, we speculated that hsa-circ-0016347 may be a potential regulator of osteosarcoma progression."
28424426
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"Our data indicated that Eag1 promotes osteosarcoma proliferation and migration, at least in part, by targeting STAT3-VEGF pathway."
26783521
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"Inhibition of Eag1 expression in tumour cell lines reduced cell proliferation."
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"XREF_BIBR - XREF_BIBR In addition, Eag1 enhances tumor cell proliferation, is involved in tumor progression and metastasis, and is associated with poor prognosis."
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"In agreement with the proliferative potential conferred by K V 10.1 (hEAG1) to different cell types [XREF_BIBR], block of hEAG1 tended to inhibit cell proliferation in both cell types."
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"In addition, suppression of Eag1 expression in several cancer cell lines causes a significant reduction of cell proliferation [XREF_BIBR, XREF_BIBR]."
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"XREF_BIBR The inhibition of Eag1 expression using antisense oligonucleotides or siRNA, or pharmacological inhibition with imipramine, astemizole or quinidine can reduce cell proliferation in cancer cell lines."
24838727
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"In addition, Eag channels have been suggested to promote the proliferation of cancer cells."
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"It has been later shown that this EAG1 channel selective increase in cell proliferation does not require K + conduction (Downie et al., 2008)."
25542181
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"Considering the latter and that calcitriol displays antineoplastic effects, while the potassium channel Ether-a-go-go (Eag1) promotes proliferation and tumor progression [13], we hypothesized that Eag[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19932096
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"Interestingly, a recent study reported that the inhibition of Eag1 inhibited the proliferation of human bone marrow derived mesenchymal stem cells, accompanied by reduced levels of cyclin D1, cyclin E, p-ERK1/2, and p-Akt [XREF_BIBR]."
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"Silencing hEAG1 by RNA interference or hEAG1 channel inhibition by monoclonal antibody has been found to remarkably suppress cell proliferation and tumor progression [8,42]."
22061963
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"It has been demonstrated that expression of a mutant form of Eag1, that can not conduct current, promotes proliferation of NIH3T3 fibroblasts and C2C12 myoblasts cells."
23970866
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"Circ_0016347 and KCNH1 promoted proliferation, migration, invasion, and glycolysis of OS cells."
33764794
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"We observed that hEag1 inhibition reduced the proliferation of several AML cell lines."
20105281
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"Blockade of IK (DR) with short hairpin RNA or human ether-a-go-go 1 (hEAG1) channel blockers, 4-AP and astemizole, significantly reduced the rate of proliferation of human iPSC-MSCs."
22357737
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"The results showed that knockdown of Eag1 significantly suppressed osteosarcoma cell proliferation and osteosarcoma xenografts growth."
26783521
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"On the contrary, Kv10.1 is overexpressed in a variety of cell lines derived from human malignancies and in different cancers including head and neck, gastric, colon, hepatocellular pancreatic, renal or prostate carcinoma [XREF_BIBR - XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR] within which Kv10.1 enhances the proliferation of the cells and is required for the maintenance of growth."
26530050
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"Collectively, these results suggest that Eag promotes the proliferation of MG-63 cells in vitro."
23450231
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"Eag1 promotes oncogenesis, proliferation and tumor progression; and therefore it is used as a marker and therapeutic target for several types of cancers XREF_BIBR, XREF_BIBR."
22984610
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"The inhibition of Eag-1 channel activity suppresses the proliferation of breast cancer cells and accumulates cells in G1 phase of the cell cycle [8,9]."
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"Two potent blockers of K V 10.1, astemizole (40, XREF_FIG) and imipramine (41) have been shown to decrease tumor cell proliferation in vitro, and, in the case of astemizole, also in vivo XREF_BIBR, XREF_BIBR - XREF_BIBR."
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"Conclusions : Eag1 may promote osteosarcoma cell proliferation and invasion by targeting STAT3-VEGF pathway and may be a potential therapeutic target for osteosarcoma."
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"In fact, selective pharmacological blockage of the HERG channel in several primary leukemic cells significantly reduced cell proliferation (Pillozzi et al., 2002; Crociani et al., 2003; Smith et al., [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Increased expression of EAG1 has been linked to certain cancers and tumor cell lines, and EAG1 inhibition by blockers, antibodies, and siRNA decreases the proliferation of tumor cell lines."
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"EAG1 enhances hepatocellular carcinoma proliferation by modulating SKP2 and metastasis through pseudopod formation."
33097858
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"Collectively, these results suggest that Eag1 promotes the proliferation of liposarcoma cells in vitro."
25136578
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"Eag silencing reduces the proliferation of osteosarcoma cells."
23450231
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"In addition, suppression of Eag1 expression in several cancer cell lines causes a significant reduction of cell proliferation, while ectopic expression of Eag1 induces aggressive tumors in immune deficient mice [XREF_BIBR - XREF_BIBR]."
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"Moreover, inhibition of EAG1 channel activity with an antibody or siRNA reduces DNA synthesis and proliferation of tumor cells."
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"Additionally, the expression of Kv10.1 positively modulates HEK293 proliferation and, certainly, prevents the effect of gamma radiation on this phenomenon."
35764005
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"These data suggested that Eag1 may promote OS proliferation and migration, at least in part, through positive regulation of STAT3-VEGF pathway."
26783521
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"Silencing of Eag1 Gene Inhibits Osteosarcoma Proliferation and Migration by Targeting STAT3-VEGF Pathway."
26783521
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"Normally, Eag1 is expressed almost exclusively in tissue of neural origin, but its ectopic expression leads to uncontrolled proliferation, while inhibition of Eag1 expression produces a concomitant reduction in proliferation."
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"However, this does not explain the observation that the proliferation of cell lines, derived from all mentioned tumor types, is reduced by inhibition of the expression or function of K V 10.1 XREF_BIBR."
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"XREF_BIBR Moreover, siRNA targeting of Eag XREF_BIBR, XREF_BIBR or non specific blockers XREF_BIBR have been shown to suppress the proliferation of tumor cells."
23450231
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"Moreover, proliferation induced by Eag1 is unaffected by changes in extracellular Ca 2+, suggesting that increased Ca 2+ influx is not an essential downstream component of Eag1 induced signaling."
23970866
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"We found that EAg pulsed dendritic cells (DCs) induced proliferation of LFA-1-deficient (CD11a -/-) CD4 + T-cells that was very similar to that induced using WT T-cells suggesting that LFA-1 is not required for activation and proliferation of T-cells in vitro."
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"In these cell lines, Eag1 enhances the proliferation of the cells, and is required for the maintenance of growth."
17022810
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"As a functional correlate, specific hEag1 blockade inhibited the proliferation and migration of several AML cell lines and primary cultured AML cells in vitro."
20105281
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"Our data help reveal possible mechanisms by which Eag1 promotes cell proliferation (XREF_FIG)."
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"So Eag1 blockers could reduce proliferation not only by inhibiting permeation, but also by trapping Eag1 in a particular conformation [XREF_BIBR]."
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"To analyze how Eag1 modulates OS cell proliferation and cell cycle progression, it is important to note that Eag1 contributes to tumor progression independently of its primary function as an ion channel."
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"Ectopic expression of miR-296-3p reduced EAG1 expression and suppressed cell proliferation drug resistance, and the luciferase activity of an EAG1 3 '-untranslated region based reporter construct in U251AR cells, whereas EAG1 over-expression rescued the suppressive effect of miR-296-3p in U251AR cells."
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"Further, pharmacologic blockade of EAG1 channel activity XREF_BIBR, XREF_BIBR, XREF_BIBR and inhibition of channel expression by RNAi interference XREF_BIBR decreased cell proliferation in tumor tissues."
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"Eag has also been shown to activate p38 MAPK and stimulate proliferation of several cell lines in a voltage dependent manner that does not require ion flux."
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"RNA interference inhibition of Eag1 and Best1 reduced proliferation of T (84)-fast cells, whereas overexpression of Best1 turned T (84)-slow into fast growing cells."
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"Collectively, these results suggest that Eag1 promotes the proliferation of OS cells in vitro."
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"In particular, transfection of Eag1 into mammalian cells confers a transformed phenotype and favors tumor progression in vivo, while inhibition of Eag1 expression inhibits cell proliferation."
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