IndraLab

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KCNH1 activates cell population proliferation. 77 / 83
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"The suppression of Eag1 expression caused a significant reduction of cancer cell proliferation XREF_BIBR - XREF_BIBR."
23569431
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"The importance of studying molecules contained in the venom of different animals that interact with Kv10.1 potassium channels rose after the finding by Dr. Pardo and collaborators in 1999 that inhibition of Kv10.1 channels causes reduced cell proliferation in different cancer cell lines [29]."
37511269
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"As a functional correlate, specific hEag1 blockade inhibited the proliferation and migration of several AML cell lines and primary cultured AML cells in vitro."
20105281
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"In addition, the short-hairpin RNA (shRNA)-mediated silencing of EAG1, a voltage-gated potassium channel, was found to inhibit proliferation and cell cycle progression in osteosarcoma [ 9 ]."
31230749
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"XREF_BIBR - XREF_BIBR In addition, Eag1 enhances tumor cell proliferation, is involved in tumor progression and metastasis, and is associated with poor prognosis."
26527881
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"Moreover, inhibition of the Kv10.1 channel can reduce proliferation of several different tumor cells [11,16,18,20,23–27] ."
32533968
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"XREF_BIBR The inhibition of Eag1 expression using antisense oligonucleotides or siRNA, or pharmacological inhibition with imipramine, astemizole or quinidine can reduce cell proliferation in cancer cell lines."
24838727
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"Eag1 Silencing Reduces the Proliferation of Osteosarcoma Cells."
23202914
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"Inhibition of Eag1 expression in tumour cell lines reduced cell proliferation."
17022810
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"In these cell lines, Eag1 enhances the proliferation of the cells, and is required for the maintenance of growth."
17022810
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"RNA interference inhibition of Eag1 and Best1 reduced proliferation of T (84)-fast cells, whereas overexpression of Best1 turned T (84)-slow into fast growing cells."
18222922
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"However, this does not explain the observation that the proliferation of cell lines, derived from all mentioned tumor types, is reduced by inhibition of the expression or function of K V 10.1 XREF_BIBR."
19949402
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"Additionally, the expression of Kv10.1 positively modulates HEK293 proliferation and, certainly, prevents the effect of gamma radiation on this phenomenon."
35764005
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"Silencing of Eag1 Gene Inhibits Osteosarcoma Proliferation and Migration by Targeting STAT3-VEGF Pathway."
26783521
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"We found that KCNH1 knockdown decreased the migration, invasion, and proliferation of RA FLSs ( Fig. 6 A-D)."
34700130
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"Two potent blockers of K V 10.1, astemizole (40, XREF_FIG) and imipramine (41) have been shown to decrease tumor cell proliferation in vitro, and, in the case of astemizole, also in vivo XREF_BIBR, XREF_BIBR - XREF_BIBR."
19949402
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"Our data indicated that Eag1 promotes osteosarcoma proliferation and migration, at least in part, by targeting STAT3-VEGF pathway."
26783521
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"Meanwhile, it has been shown that KCNH1 and KCNH2 accelerate the proliferation of non-excitable cell-derived cancer cells, which has nothing to do with their ion conduction function [41,42]."
38905316
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"Eag has also been shown to activate p38 MAPK and stimulate proliferation of several cell lines in a voltage dependent manner that does not require ion flux."
19130887
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"XREF_BIBR Moreover, siRNA targeting of Eag XREF_BIBR, XREF_BIBR or non specific blockers XREF_BIBR have been shown to suppress the proliferation of tumor cells."
23450231
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"We observed that hEag1 inhibition reduced the proliferation of several AML cell lines."
20105281
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"Proanthocyanidin B1, a natural compound extracted from grape seeds, is a specific inhibitor of Kv10.1 channels, and inhibition of Kv10.1 currents can inhibit migration, proliferation, and xenograft tumor development in the hepatoma cell line Hh-7 cells as well as HepG2 cells (72)."
36703789
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"The results showed that knockdown of Eag1 significantly suppressed osteosarcoma cell proliferation and osteosarcoma xenografts growth."
26783521
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"Further, pharmacologic blockade of EAG1 channel activity XREF_BIBR, XREF_BIBR, XREF_BIBR and inhibition of channel expression by RNAi interference XREF_BIBR decreased cell proliferation in tumor tissues."
20824064
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"For example, KCNH1 knockdown suppresses proliferation and migration of osteosarcoma [21] ."
34700130
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"KCNH1 knockdown reduced proliferation, migration, invasion and expression of MMP-1 and MMP-13 in RA FLSs."
34700130
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"It has been demonstrated that expression of a mutant form of Eag1, that can not conduct current, promotes proliferation of NIH3T3 fibroblasts and C2C12 myoblasts cells."
23970866
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"These data suggested that Eag1 may promote OS proliferation and migration, at least in part, through positive regulation of STAT3-VEGF pathway."
26783521
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"Increased expression of EAG1 has been linked to certain cancers and tumor cell lines, and EAG1 inhibition by blockers, antibodies, and siRNA decreases the proliferation of tumor cell lines."
22930803
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"Circ_0016347 and KCNH1 promoted proliferation, migration, invasion, and glycolysis of OS cells."
33764794
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"Moreover, proliferation induced by Eag1 is unaffected by changes in extracellular Ca 2+, suggesting that increased Ca 2+ influx is not an essential downstream component of Eag1 induced signaling."
23970866
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"Knockdown of Eag1 inhibited the GC cell proliferation, whereas knockdown of Eag1 decreased G -S phase cell cycle progression."
36388037
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"The precise mechanism how K V 10.1 promotes proliferation of cancer cells is still under debate, although it is known that it includes both permeation dependent and -independent components."
22022602
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"EAG1 enhances hepatocellular carcinoma proliferation by modulating SKP2 and metastasis through pseudopod formation."
33097858
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"Moreover, inhibition of EAG1 channel activity with an antibody or siRNA reduces DNA synthesis and proliferation of tumor cells."
23440277
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"We found that EAg pulsed dendritic cells (DCs) induced proliferation of LFA-1-deficient (CD11a -/-) CD4 + T-cells that was very similar to that induced using WT T-cells suggesting that LFA-1 is not required for activation and proliferation of T-cells in vitro."
22488891
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"Silencing hEAG1 by RNA interference or hEAG1 channel inhibition by monoclonal antibody has been found to remarkably suppress cell proliferation and tumor progression [8,42]."
22061963
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"Importantly, pharmacological inhibition of Kv10.1 channels decreases proliferation and migration of several cancer cell lines ( Asher et al., 2011 ; Bernal-Ramos et al., 2017 ; Hammadi et al., 2012 ; [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31082369
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"Finally, siRNA mediated knockdown of Eag1 expression reduces proliferation, and the inhibition of channel function reduces tumor progression both in vitro and in vivo."
18927085
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"In fact, selective pharmacological blockage of the HERG channel in several primary leukemic cells significantly reduced cell proliferation (Pillozzi et al., 2002; Crociani et al., 2003; Smith et al., [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17976575
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"Eag silencing reduces the proliferation of osteosarcoma cells."
23450231
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"Reciprocally, Eag1 appears to be involved in cell cycle (Borowiec et al., 2007); cells expressing Eag1 grow faster than control cells, and inhibition of Eag1 expression reduces cell proliferation (Borowiec et al., 2007)."
22276743
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"In agreement with the proliferative potential conferred by K V 10.1 (hEAG1) to different cell types [XREF_BIBR], block of hEAG1 tended to inhibit cell proliferation in both cell types."
22919401
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"On the other hand, Eag1 overexpression promoted the colony-formation capability and proliferation of the cells."
37654193
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"Conclusions : Eag1 may promote osteosarcoma cell proliferation and invasion by targeting STAT3-VEGF pathway and may be a potential therapeutic target for osteosarcoma."
27998439
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"Based on the findings in previous studies that potassium voltage gated channel subfamily H member 1 (KCNH1) was overexpressed in osteosarcoma and promoted the proliferation and invasion of osteosarcoma [XREF_BIBR - XREF_BIBR] and on our profile of the miRanda, PITA, RNAhybrid databases to explore the corresponding circRNAs of KCNH1, we speculated that hsa-circ-0016347 may be a potential regulator of osteosarcoma progression."
28424426
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"On the contrary, Kv10.1 is overexpressed in a variety of cell lines derived from human malignancies and in different cancers including head and neck, gastric, colon, hepatocellular pancreatic, renal or prostate carcinoma [XREF_BIBR - XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR] within which Kv10.1 enhances the proliferation of the cells and is required for the maintenance of growth."
26530050
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"In these cell lines, eag1 enhances the proliferation of the cells XREF_BIBR, and is required for the maintenance of growth."
21655246
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"Collectively, these results suggest that Eag promotes the proliferation of MG-63 cells in vitro."
23450231
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"Transfection of the Drosophila Kv10.1 channel into mammalian cultured cells stimulated cell proliferation."
35955591
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"Nevertheless, in T colonic carcinoma cells, hyperpolarization of the membrane potential induced by Kv10.1 (and other Kv channels) controls cell proliferation by affecting intracellular pH and Ca signaling [114]."
35955591
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"Normally, Eag1 is expressed almost exclusively in tissue of neural origin, but its ectopic expression leads to uncontrolled proliferation, while inhibition of Eag1 expression produces a concomitant reduction in proliferation."
16362499
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"In particular, transfection of Eag1 into mammalian cells confers a transformed phenotype and favors tumor progression in vivo, while inhibition of Eag1 expression inhibits cell proliferation."
15365094
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"Considering the latter and that calcitriol displays antineoplastic effects, while the potassium channel Ether-a-go-go (Eag1) promotes proliferation and tumor progression [13], we hypothesized that Eag[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19932096
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"Eag1 promotes oncogenesis, proliferation and tumor progression; and therefore it is used as a marker and therapeutic target for several types of cancers XREF_BIBR, XREF_BIBR."
22984610
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"In addition, Eag channels have been suggested to promote the proliferation of cancer cells."
15365094
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"Inhibition of EAG1 expression has been shown to reduce cell proliferation 71."
38230221
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"Blockade of IK (DR) with short hairpin RNA or human ether-a-go-go 1 (hEAG1) channel blockers, 4-AP and astemizole, significantly reduced the rate of proliferation of human iPSC-MSCs."
22357737
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"The inhibition of Eag-1 channel activity suppresses the proliferation of breast cancer cells and accumulates cells in G1 phase of the cell cycle [8,9]."
21315112
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"For instance, inhibitors of Kv10.1 and hERG channels have been shown to reduce proliferation and induce apoptosis in BC cells (Peretti et al., 2019)."
40110186
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"In addition, suppression of Eag1 expression in several cancer cell lines causes a significant reduction of cell proliferation, while ectopic expression of Eag1 induces aggressive tumors in immune deficient mice [XREF_BIBR - XREF_BIBR]."
25136578
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"Eag1 Blockage Reduces the Proliferation of Liposarcoma Cells."
25136578
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"Collectively, these results suggest that Eag1 promotes the proliferation of liposarcoma cells in vitro."
25136578
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"So Eag1 blockers could reduce proliferation not only by inhibiting permeation, but also by trapping Eag1 in a particular conformation [XREF_BIBR]."
25136578
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"It has been proposed recently that perinuclear localization of Eag1 could lead to the activation of MAPK pathway, resulting in increased cell proliferation [XREF_BIBR]."
25136578
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"In addition, suppression of Eag1 expression in several cancer cell lines causes a significant reduction of cell proliferation [XREF_BIBR, XREF_BIBR]."
24694542
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"Collectively, these results suggest that Eag1 promotes the proliferation of OS cells in vitro."
24694542
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"The inhibition of Eag1 channels reduced cancer cell proliferation and also inhibited tumor growth in vivo [67]."
32429050
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"To analyze how Eag1 modulates OS cell proliferation and cell cycle progression, it is important to note that Eag1 contributes to tumor progression independently of its primary function as an ion channel."
24694542
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"Inhibition of Eag1 expression by siRNA or shRNA decreases proliferation and migration in SaOS-2 and GM-63 [11,19], however, the effects produced by the blockade of Eag1 on Ca deposition have not been investigated yet.Based on these, we designed experiments to test the functional expression of hEag1 K channels in SaOS-2 osteosarcoma cells and to determine if pharmacological modulation of the channel may play a role in the regulation of osteogenic differentiation."
36142445
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"Interestingly, a recent study reported that the inhibition of Eag1 inhibited the proliferation of human bone marrow derived mesenchymal stem cells, accompanied by reduced levels of cyclin D1, cyclin E, p-ERK1/2, and p-Akt [XREF_BIBR]."
24694542
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"Our data help reveal possible mechanisms by which Eag1 promotes cell proliferation (XREF_FIG)."
24694542
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"HEag1 inhibition is known to reduce the proliferation of cancer cells [6,57,58,59,60,61,62] and thus, astemizole was expected to reduce the cell proliferation."
36142445
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"It has been later shown that this EAG1 channel selective increase in cell proliferation does not require K + conduction (Downie et al., 2008)."
25542181
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"In vitro and in vivo studies showed that Kv10.1 suppression via known Kv10.1 inhibitors, targeted monoclonal antibodies or using siRNA generated apoptosis and decreased cell proliferation and migration, while also sensitized tumor cells to antimetabolic agents [50–53]."
38154047
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"They reported that silencing Eag1 reduced the viability and proliferation of the U87MG glioblastoma cell line and increased the apoptotic rate triggered by temozolomide (TMZ) [148], clearly pointing out and confirming a role for potassium channels (Eag1) in modulation apoptosis in a glioma context."
37103862
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"In this study, we verified that EAG1 promotes the proliferation of hepatocellular carcinoma (HCC) both in vitro and in vivo."
33097858