IndraLab

Statements

TBK1 phosphorylates CYLD on S418. 8 / 8
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rlimsp
"Interestingly, immunoprecipitation with the phospho(Ser418)-CYLD antibody, followed by immunoblotting with anti-CYLD, revealed that CYLD is phosphorylated by IKKε/TBK1 at Ser418 upon T cell stimulation, but that its direct detection with the phospho(Ser418)-CYLD-specific antibody in a western blot is masked by another inducible protein of the same size that is recognized by the same antibody."
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"The TCR- and PMA/I induced Ser418 phosphorylation of CYLD could be completely prevented by dual inhibition of IKKepsilon and TBK1, using MRT67307, while the IKKbeta inhibitor TPCA1 had no effect."
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"Our initial data indicated that CYLD is directly phosphorylated by the noncanonical IkappaB kinases (IKKs) IKKepsilon and TANK Binding Kinase 1 (TBK1) at Ser418 upon TCR stimulation."
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"IKKepsilon and TBK1 are activated upon T cell activation and can directly phosphorylate CYLD at Ser418."
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"IKKε and TBK1 are activated upon T cell activation and can directly phosphorylate CYLD at Ser418."
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"Interestingly, immunoprecipitation with the phospho (Ser418)-CYLD antibody, followed by immunoblotting with anti-CYLD, revealed that CYLD is phosphorylated by IKKepsilon and TBK1 at Ser418 upon T cell stimulation, but that its direct detection with the phospho (Ser418)-CYLD-specific antibody in a western blot is masked by another inducible protein of the same size that is recognized by the same antibody."
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"Further, in an in vitro kinase assay we could show that recombinant IKKepsilon and TBK1 can directly phosphorylate CYLD at Ser418."
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"Further, in an in vitro kinase assay we could show that recombinant IKKε and TBK1 can directly phosphorylate CYLD at Ser418 (Figure xref )."
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