IndraLab

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L18-MDP activates OTULIN. 2 / 2
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"Notably, ubiquitinated RIPK2 was readily detected in the lysates from OTULIN depleted cells treated with L18-MDP, illustrating extensive ubiquitination of RIPK2 when OTULIN is depleted."

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"In line with this, Met1-Ub on RIPK2 was barely detectable in control cells subjected to the low concentration of L18-MDP but accumulated in the OTULIN depleted cells to levels comparable with those in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"