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UCHL5 activates Wnt/β-catenin. 10 / 10
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"To further confirm whether the UCHL5-regulated cell phenotype in EC cells was mediated by the Wnt/β-catenin signaling pathway, Wnt/β-catenin inhibitor XAV939 was used in the present study."
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"Additionally, a study on endometrial cancer observed that UCHL5 accelerates tumor growth by activating the Wnt/β-catenin signaling pathway [50]."
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"First, we discovered that UCHL5 stimulates the Wnt/β-catenin pathway in tumor cells to enhance glycolysis."
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"We overexpressed UCHL5 while inhibiting β-catenin or adding a β-catenin inhibitor to further determine if UCHL5 accelerates HCC development by stimulating the Wnt/β-catenin pathway."
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"In conclusion, our results that UCHL5 promoted the growth of EC in vivo and vitro via activating the Wnt/β-catenin signaling pathway may provide potential targets for EC control in the future."
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"In addition, UCHL5 overexpression mediated by lentivirus vectors activated Wnt/β-catenin signaling in endometrial cancer cells and resulted in a decrease in apoptosis and an increase in proliferation."
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"Da Liu et al. reported that UCHL5 could accelerate endometrial cancer growth by triggering Wnt/β-catenin signaling [20]."
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"Additionally, UCHL5 knockdown caused a significant reduction in β-catenin and c-Myc levels, key components of the Wnt/β-catenin signaling pathway, suggesting that UCHL5 may stabilize β-catenin and facilitate Wnt/β-catenin signaling (Fig. 9G)."
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"The corrected Figure 5 and its caption “UCHL5 activated Wnt/β-catenin signaling and affected the expression of its target genes."
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"Our study’s findings demonstrate that altering UCHL5 expression can control the mRNA expression levels of markers associated with metabolism, including GLUT1, PKM2, HK2, and LDHA, and further encourage the growth of glycolysis.In this work, we discovered that UCHL5 triggers Wnt/β-catenin to activate glycolysis."
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