Other Services

This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Kinase-active RAF1 leads to the phosphorylation of MAP2K1 on S222. 2 / 2

2 |

➶

bel

"To address a possible role of mutant C-RAF proteins in the constitutive phosphorylation of ERK1/2, kinase assays were done with Myc-tagged C-RAF proteins immunoprecipitated from transiently transfected Cos-7 cells. Strong constitutive kinase activity was shown for S427GC-RAF whereas I448VC-RAF did not significantly differ from wt C-RAF (Fig. 3A)."

16585161

➶

bel

"Raf-1 activity, measured by the abundance of phosphorylated S217/221 MEK1 2, a direct target of Raf-1 (30) , was consistently elevated in Cdc37 overexpressing cells, whereas total MEK1 2 levels were unchanged."

12907640

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...