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AKT phosphorylates NOS3 on serine. 5 / 5
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"Akt kinase, which can phosphorylate eNOS Ser (1177), was also decreased by hypoxia, regarding both total protein content and the phosphorylated (active) form."
17720765
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"Activated Akt phosphorylates eNOS at Ser , a major activation site (Dimmeler et al., 1999; Fulton et al., 1999; Michell et al., 1999), which is enhanced by its interaction with heat shock protein 90 (Fulton et al., 2001; Fontana et al., 2002; Venema, 2002)."
20045558
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"To conclude, the mouse pulmonary endothelial beta2-AR is coupled to a G (i/o)-Src kinase-PI3K and Akt pathway to promote eNOS phosphorylation at Ser (1177) leading to a NO dependent vasorelaxation."
21385608
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"Taken together, research published results show that the stimulation of PI3K and Akt by shear stress and VEGF elicits the serine phosphorylation of eNOS, and thereby enhances enzyme activity in a Ca ++ -independent manner XREF_BIBR."
26386874
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"Insulin plays a critical role in the maintenance of physiological endothelial function through its ability to stimulate NO release via a cascade that involves activation of the PI3K-Akt signaling and downstream serine phosphorylation of eNOS."
22611498