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UCHL1 activates BCL2. 2 / 2
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"Moreover, three apoptotic regulation factors Bcl-2, Bax and caspase3 were evaluated by western blot which showed that the proteins promoting apoptosis (Bax and caspase3) were up-regulated and the prot[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The results indicated that probably the extrinsic (Fas, Fas-L, Trail, DR4 and DR5) and intrinsic (cytochrome C) apoptotic pathways, the activation of p53 (phospho-Mdm-2 and phospho-p53) and the Bcl-2 family members (pro apoptotic member Bax, anti-apoptotic members Bcl-2 and Bcl-xL) combined with each other, participating in the process of apoptosis induced by UCH-L1 in MCF7 cells."
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