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Calcium(2+) activates CACNA1A. 10 / 11
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"In FSIs, repolarization is mostly determined by Kv3.1 (Rudy and McBain, 2001), making typical fast-spiking narrow action potentials, while large conductance Ca -sensitive K channels (BK channels) determine repolarization in ChIs activated by Ca influx through Cav2.1 (Goldberg and Wilson, 2005)."
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"Our results indicate that the tg mutation causes a dominant disorder of the hippocampus-related memory and synaptic plasticity, raising the possibility that in CACNA1A-associated human diseases, functionally aberrant Ca V 2.1 Ca 2+ channels actively induce the observed cognitive deficits independently of the neurological symptoms."
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"The proteins were injected together with 100 mM BAPTA, and thus, should be in the apo-forms and remain so until the local calcium concentration is raised via voltage-dependent Ca V 1.2 activation."
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"It has been hypothesised that in the aged hippocampus long-term potentiation expression is more dependent on voltage-dependent Ca channel activation than in the young brain ()."
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"Wagner-Britz et al. have also reported the different routes of calcium entry between PKC-mediated calcium influx and CaV2.1 channel activity in erythrocytes [47] ."
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"As previously observed for the skeletal muscle CRC (), a strong voltage-dependence of channel activities was observed in the presence of elevated levels of lumenal, but not cytosolic, Ca. A voltage-de[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"SCA6 is caused by the CAG repeat expansion of C terminus of Ca v 2.1 subunit, which results in alteration of Ca v 2.1 channel's function [10] ."
20181362
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"SCA6 is caused by a CAG repeat expansion encoding polyglutamine in the CACNA1A gene (calcium voltage-gated channel subunit alpha1)."
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"For example, Ca -bound N-lobe produces CDI of Cav2.1 (P/Q type) channels, while Ca -bound C-lobe produces CDF [40]."
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"We further mechanistically evaluated this premise using an allosteric model of voltage-dependent Ca V activation."
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