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Calcium(2+) activates CACNA1A. 5 / 6
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"It has been hypothesised that in the aged hippocampus long-term potentiation expression is more dependent on voltage-dependent Ca channel activation than in the young brain ()."
10422760
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"As previously observed for the skeletal muscle CRC (), a strong voltage-dependence of channel activities was observed in the presence of elevated levels of lumenal, but not cytosolic, Ca. A voltage-de[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9788925
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"We further mechanistically evaluated this premise using an allosteric model of voltage-dependent Ca V activation."
27481713
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"Our results indicate that the tg mutation causes a dominant disorder of the hippocampus-related memory and synaptic plasticity, raising the possibility that in CACNA1A -associated human diseases, functionally aberrant Ca V 2.1 Ca 2+ channels actively induce the observed cognitive deficits independently of the neurological symptoms."
35548926
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"The proteins were injected together with 100 mM BAPTA, and thus, should be in the apo-forms and remain so until the local calcium concentration is raised via voltage-dependent Ca V 1.2 activation."
23811053