IndraLab

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USP2 inhibits calcium(2+). 2 / 2
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"In summary, we found that the inactivation of Usp2 in mouse and of its orthologue CG14619 in Drosophila does not affect the circadian free running period, but impairs bodily Ca 2+ homeostasis in both species, especially in dietary Ca 2+ absorption in mouse small intestine."
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"USP2 overexpression suppressed the degree of cardiac hypertrophy (decreased ANP, BNP, and β-MHC mRNA levels, cell surface area, and ratio of protein/DNA), calcium overload (decreased Ca 2+ concentration and t-CaMKⅡ and p-CaMKⅡ, and increased SERCA2), and mitochondrial dysfunction (decreased MDA and ROS and increased MFN1, ATP, MMP, and complex Ⅰ and II) both in vitro and in vivo."
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