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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

EGFR bound to EGF activates STAT3. 2 / 2

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"With respect to pre-EMT carcinoma cells, STAT3 is predominantly activated by the binding of EGF to EGFR (i.e., EGF dependent; XREF_FIG, left), and to a lesser extent, by the binding of FN to a complex comprised of alphavbeta3 integrin and EGFR (i.e., EGF independent; XREF_FIG, middle)."

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"The binding of EGF to EGFR leads to an activation of Stat3 and subsequently a Stat3 induced increased expression of TWIST [XREF_BIBR]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...