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PKC activates SCN5A. 3 / 3
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"Furthermore, it was shown that a cocktail of inflammatory mediators containing bradykinin, PGE-2, histamine, 5-HT, and adenosine 5 -triphosphate altered the gating properties of Nav1.5 and both protein kinase A and protein kinase C mediated the inflammatory mediators induced alteration in the gating properties of Nav1.5 [24] ."

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"In this study, we tested the hypothesis that PKC activation acutely modulates the intracellular distribution of SCN5A channels and that this effect can be visualized in living cells."

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"Taken together, these results with Tx are similar to those obtained previously with phorbol ester application and alpha-adrenergic receptor stimulation [7], suggesting that PKC modulates hH1 current b[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"