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PSMD14 increases the amount of MYC. 3 / 3
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"Consistent with the genetic loss of POH1, capzimin treatment down-regulated MYC protein expression in PDAC tissues ( Fig. 6 E), indicating that targeting POH1 is effective in inhibiting MYC protein."
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"Subsequently, we evaluated whether POH1 regulates MYC in vivo , and found that POH1 deficiency in KPC mice significantly reduced MYC protein levels as determined by immunohistochemical staining ( Fig.[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, the use of POH1-specific inhibitors, such as capzimin, significantly down-regulated MYC protein levels, providing a potential avenue for targeting this essential driver gene.Pancreatic ducta[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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