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Celecoxib inhibits SCN5A. 3 / 3
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"In the present study we examined if celecoxib could inhibit human SCN5A."
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"Celecoxib inhibited the hERG, SCN5A, KCNQ1 and KCNQ1 and MinK channels expressed in HEK-293 cells with IC 50 s of 6.0 microM, 7.5 microM, 3.5 microM and 3.7 microM respectively, and the KCND3 and KChiP2 channels expressed in CHO cells with an IC 50 of 10.6 microM."
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"In addition, we explored if celecoxib inhibited human SCN5A channels, examined concentration dependence of inhibition of human KCNQ1, KCNQ1 and MinK and KCND3 and KChiP2 channels XREF_BIBR, and studied the nature of inhibition of human KCNQ1 and MinK channels."
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