IndraLab

Statements

PAN2 is phosphorylated on S1003. 3 / 3
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"We next examined which SQ/TQ site of USP52 was phosphorylated and found that the S1003A but not S469A mutation mostly abolished the phosphorylation of USP52 after DNA damage (Fig.  xref and Supplementary Fig.  xref ), suggesting that USP52 is phosphorylated on Ser-1003 in an ATM-dependent manner following IR treatment."
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"These results suggest that phosphorylation of USP52 S1003 plays a vital role in regulating the DUB activity of USP52."
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"To further examine whether the phosphorylation of USP52 at S1003 regulates CtIP deubiquitination, we reconstituted WT or the S1003A mutants in USP52-deficient cells and examined the ubiquitination level of CtIP with or without IR treatment."
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