IndraLab

Statements

ATXN3 increases the amount of SOD2. 3 / 5
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"Ataxin-3 has been shown to activate transcription factor forkhead box protein O4 (FOXO4) and induce the expression of manganese superoxide dismutase (SOD2), an antioxidant enzyme, under oxidative stress conditions; however, when ataxin-3 is expanded, this transcriptional activation effect is reduced and, in fact, SOD2 levels are decreased in SCA3 patients brain samples ."
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"Finally and consistent with a regulatory role of ATXN3 in SOD2 expression, knockdown of endogenous ATXN3 by RNA interference represses the expression of SOD2."
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"ATXN3 interacts with and stabilizes the forkhead box O (FOXO) transcription factor FOXO4, and upon oxidative stress they both translocate to the nucleus and activate manganese superoxide dismutase (SOD2) transcription which in turn protects cells from oxidative damage."
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