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USP10 deubiquitinates AMPK_alpha. 9 / 9
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"Mechanistically, following the energy deprivation, USP10 largely deubiquitinates AMPKalpha so that its activating phosphorylation by LKB1 could be greatly enhanced."
27681874
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"As shown in XREF_FIG and XREF_SUPPLEMENTARY, knockdown of USP10 increased the ubiquitination of WT AMPKalpha; on the other hand, knockdown of USP10 did not affect ubiquitination levels of the AMPKalpha 4KR mutant (XREF_FIG and XREF_SUPPLEMENTARY)."
26876938
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"We further overexpressed WT USP10 or catalytic inactive mutant in USP10 deficient cells and found that WT USP10, but not the CA mutant decreased ubiquitination of AMPKalpha (XREF_FIG and XREF_SUPPLEMENTARY), suggesting that USP10 regulates AMPKalpha ubiquitination in cells."
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"In this study, we identified that USP10 can deubiquitinate PTEN and AMPKalpha and the stabilization of these two proteins will subsequently suppress the activation of AKT and mTOR in HCC cells."
30056112
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"As shown in Figures 3 E and S3 D, knockdown of USP10 increased the ubiquitination of WT AMPKalpha; on the other hand, knockdown of USP10 did not affect ubiquitination levels of the AMPKalpha 4KR mutan[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26876938
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"We further overexpressed WT USP10 or CA mutant in USP10 deficient cells and found that WT USP10, but not the CA mutant, decreased ubiquitination of AMPKalpha, suggesting that USP10 regulates AMPKalpha[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26876938
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"USP10 interacts with AMPK and deubiquitinates AMPKalpha."
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"In addition, in line with our study, two different groups have also reported that USP10 deubiquitinates and stabilizes PTEN and AMPKalpha in lung cancer and colon cancer cells [16, 27]."
30056112
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"Recently, it was established that USP10 deubiquitinates AMPKalpha to promote its interaction with LKB1, its master regulator and thus enhances its activity."
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