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USP10 deubiquitinates AMPK_alpha. 7 / 7
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"USP10 interacts with AMPK and deubiquitinates AMPKalpha."

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"In this study, we identified that USP10 can deubiquitinate PTEN and AMPKalpha and the stabilization of these two proteins will subsequently suppress the activation of AKT and mTOR in HCC cells."

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"In addition, in line with our study, two different groups have also reported that USP10 deubiquitinates and stabilizes PTEN and AMPKalpha in lung cancer and colon cancer cells [16, 27]."

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"Recently, it was established that USP10 deubiquitinates AMPKalpha to promote its interaction with LKB1, its master regulator and thus enhances its activity."

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"We further overexpressed WT USP10 or catalytic inactive mutant in USP10 deficient cells and found that WT USP10, but not the CA mutant decreased ubiquitination of AMPKalpha (XREF_FIG and XREF_SUPPLEMENTARY), suggesting that USP10 regulates AMPKalpha ubiquitination in cells."

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"Mechanistically, following the energy deprivation, USP10 largely deubiquitinates AMPKalpha so that its activating phosphorylation by LKB1 could be greatly enhanced."

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"As shown in XREF_FIG and XREF_SUPPLEMENTARY, knockdown of USP10 increased the ubiquitination of WT AMPKalpha; on the other hand, knockdown of USP10 did not affect ubiquitination levels of the AMPKalpha 4KR mutant (XREF_FIG and XREF_SUPPLEMENTARY)."