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USP7 activates UHRF1. 4 / 5
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"Thus , we predicted that the HPV E6 / E7 oncoproteins might induce expression of USP7 , which in turn , promotes UHRF1 activity and consequently , down-regulates TXNIP expression ."
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"However, TQ induced HAUSP and UHRF1 deregulation needs further investigation to decipher the molecular events involved, namely the HAUSP down-regulation, which triggers UHRF1 down-regulation followed by apoptosis."
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"Taken together, these data indicate that USP7 stabilizes UHRF1 protein levels in vivo and suggest that USP7 removes ubiquitin adducts from UHRF1 and therefore prevents proteasomal degradation of UHRF1."
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"We further showed that down-regulation of UHRF1 promoted cell cycle arrest and apoptosis, and overexpression of HPV E6/E7 induced ubiquitin specific protease 7 (USP7), which promoted UHRF1 function, leading to TXNIP inhibition."
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