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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Kinase-active EGFR leads to the phosphorylation of MET on tyrosine. 2 / 2

2 |

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bel

"Treatment of Caco-2 and LoVo cells with PGE2 (10 micromolar, 5 mins) significantly increased c-met-R phosphorylation. when these cells were treated with a specific inhibitor Tryphostin AG 1478 of EGFR, PGE2 almost completely inhibited PGE2-induced c-met-R phosphorylation, indicating that functional EGFR is required for PGE2-induced c-Met-R activation."

12958170

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bel

"Inhibitors of Src (PP2, SU6656) or EGFR (AG99), but not p145(met) (K252a), effectively blocked tyrosine phosphorylation of p145(met) and promoted cell death accompanied by activation of caspase-like proteases."

17062641

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...