IndraLab

Statements

USP7 decreases the amount of FOXP3. 3 / 3
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"In fact, USP7 expression is highly upregulated in FOXP3 + Tregs, whereas USP7 downregulation or inhibition causes loss of FOXP3 and impairs Treg functions."
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"To further validate that USP7 directly reduced Foxp3 protein expression because of enhanced degradation and not indirectly through additional mechanisms, we analyzed the activation status of multiple signaling pathways in the presence or absence of USP7."
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"Excitingly, the authors of this study 82 also found that the in vivo administration of a specific USP7 antagonist inhibited FOXP3 expression and the suppressive activity of T reg cells in tumour bearing mice."
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