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BAP1 inhibits cell population proliferation. 46 / 50
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"BAP1 enhances BRCA1 mediated suppression of cell proliferation through stabilizing BRCA1 [XREF_BIBR]."
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"BAP1 suppresses MM cell proliferation."
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"In contrast to melanoma cells, stable overexpression of BAP1 into immortalized but non transformed melanocytes did suppress proliferation and reduce survivin."
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"Results BAP1 promotes proliferation in HNSCC cells regardless of HPV status Studies of the effects of BAP1 on cell proliferation have shown conflicting results , with some reporting that BAP1 suppresses cell proliferation ( 12 , 13 ) , and others reporting that BAP1 enhances proliferation ( 14 , 15 ) ."
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"As shown in XREF_FIG, stable introduction of BAP1 into Pmel cells (i.e. Pmel (BAP1)) reduced proliferation, colony forming capacity and survivin levels."
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"Wild-type BAP1 but not mutant BAP1 significantly inhibited HCC cell proliferation, invasion, epithelial-mesenchymal transition (EMT) in vitro, and tumor progression and metastasis in vivo."
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"BAP1 suppresses the proliferation of some cell types."
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"BRCA1 Associated Protein-1 Suppresses Osteosarcoma Cell Proliferation and Migration Through Regulation PI3K and Akt Pathway."
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"One intact allele of the BAP1 gene on chromosome 3 is requisite for the expression and translocation to the nucleus where BAP1 can inhibit tumor proliferation. xref Suppression of the nuclear localization of BAP1 (biallelic suppression) occurs in monosomy 3 because it is combined with assorted mutations on the remaining allele that may truncate the BAP1 protein, or affect nuclear localizer regions. xref BAP1 has definite additional prognostic value compared to the aforementioned tests and unlike the other prognostic tests permits microscopic confirmation of tumor."
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"As BAP1 can both promote and suppress cell proliferation based on the cell types, its ability to repress cellular growth in vitro does not necessarily correlate with its major tumor suppressor function in vivo [XREF_BIBR]."
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"We also provided evidence that BAP1 suppressed cell proliferation and promoted cell apoptosis, suggesting that BAP1 tended to function as a tumor suppressor in lung cancer."
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"In vitro , BAP1 inhibited proliferation and EMT."
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"The addition of Bap1 loss increased tumor proliferation and cutaneous melanoma size."
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"In vivo results using a chicken embryo choriollantoic membrane (CAM) assay showed that BaP1 inhibits tumor growth, angiogenesis, and tumor proliferation."
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"An analysis of multiple lung cancer cell lines identified a cell line with biallelic inactivation suggesting that BAP1 may be a two-hit tumor suppressor gene. xref Subsequently, BAP1 overexpression was shown to inhibit proliferation, and this effect was compromised by mutations disrupting catalytic activity or nuclear localization. xref However, the inhibition of cell proliferation by BAP1 is cell type specific. xref , xref , xref In NCI-H226, where BAP1 suppresses cell proliferation, ectopic BAP1 expression also inhibited tumor formation in xenografts. xref "
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"XREF_BIBR, XREF_BIBR, XREF_BIBR In NCI-H226, where BAP1 suppresses cell proliferation, ectopic BAP1 expression also inhibited tumor formation in xenografts."
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"As anticipated, A549 cells transfected with the BAP1 siRNA proliferated at a higher rate (XREF_SUPPLEMENTARY), whereas BAP1 overexpression decreased cell proliferation (XREF_SUPPLEMENTARY)."
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"Additionally, BAP1 inhibits cell proliferation by deubiquitinating host cell factor-1 (HCF1) [XREF_BIBR]."
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"XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR In MPM, BAP1 depletion in 3 different cell lines reduced cell proliferation."
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"62 However, the inhibition of cell proliferation by BAP1 is cell type specific."
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"In a RCC cell line with BAP1 mutation, 769-P, cell proliferation was inhibited by the introduction of wild type BAP1 [XREF_BIBR]."
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"These results indicated that BAP1 suppressed ICC cell proliferation, cell cycle progression, and invasion via inhibiting ERK1/2 and JNK/c-Jun signaling pathways.To further validate these findings, we used inhibitors of the ERK1/2 pathway (U0126) and JNK/c-Jun pathway (SP600125) in RBE-shBAP1 cells."
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"In melanoma cells, genetic deletion of BAP1 decreases cell proliferation and tumor growth in vivo; however, BAP1 overexpression in non-transformed melanocytes likewise decreases proliferation (44)."
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"Genetic depletion of BAP1 in melanoma cells reduced proliferation and colony forming capability, induced apoptosis and inhibited melanoma tumor growth in vivo."
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"Rescue expression of BAP1, but not BAP1-C91A in two neuroblastoma cells lines reduced the proliferation rate at 48 and 72h, compared with control cells."
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"Conversely, BAP1 genetic deletion in mouse primary melanocytes and mesothelial cells induces proliferation and the expression of pro-survival genes."
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"Our results suggested that, whereas WT BAP1 suppresses MM cell proliferation and restores cell survival after IR damage, some mutant BAP1 may also moderately retain these functions."
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"All of these results further confirmed that BAP1 suppressed ICC cell proliferation, cell cycle progression, and invasion via inhibiting ERK1/2 and JNK/c-Jun signaling pathways."
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"BAP1 promotes cell death and suppresses cell proliferation in LAC."
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"BAP1 depletion by RNAi inhibits cell proliferation as does overexpression of a dominant negative mutant of BAP1."
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"A previous study on the expression of BAP1 tumor suppressor gene in 1222 patients with TCGA breast cancer data reported that the expression of BAP1, which enhances BRCA1-mediated suppression of cell proliferation through BRCA1 stabilization, is highly correlated with USP19 expression."
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"Although paradoxical for a gene whose genetic alterations support a tumor suppressor function, these data are consistent with previous studies of non MPM cell lines in which BAP1 knockdown caused proliferation defects with an accumulation of cells in S phase XREF_BIBR - XREF_BIBR."
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"The addition of BAP1 loss increased tumor proliferation and melanoma size."
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"However, BAP1 did not completely abrogate cell proliferation."
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"BAP1 depletion diminished proliferation, and enhanced apoptosis, both in vitro and in vivo, and phenotypically inhibited tumor growth in mice xenografts."
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"In the same study, inactivation of BAP1 in clear cell renal cell carcinoma cell lines altered cellular proteostasis, suppressed cell proliferation, and induced a mesenchymal-to-epithelial-like phenotype [45], suggesting that the role of BAP1 in tumor progression may be more complex than its presumed tumor suppressor function [46]."
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"Transduction of the WT BAP1 vector inhibited cell proliferation of the Y-MESO-25 MM cell line with BAP1 deletion by approximately 50% compared to the cells with control vector (GFP)."
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"Likewise, cell proliferation, G1-phase to S-phase cell cycle progression, and invasion of HCCC9810 cells were significantly inhibited by transfection of wild-type BAP1 but not inactive mutant BAP1C91A (Fig. 4c, d)."
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"As in 769-P cells, (i) cell proliferation was inhibited by wild-type BAP1 and substantially less so by an HBM mutant, (ii) the HBM mutant reduced H2Aub1 levels, (iii) BAP1 cofractionated with HCF-1, and (iv) restoration of BAP1 protected UMRC6 cells against genotoxic death (XREF_SUPPLEMENTARY)."
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"Additionally, BAP1 inhibits cell proliferation by deubiquitinating host cell factor-1 (HCF1) [ xref ]."
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"LaFave et al. [XREF_BIBR] reported that loss of BAP1 promotes MPM cell proliferation by upregulating EZH2."
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"18 The inhibition of cell proliferation by BAP1 was compromised by disruption of the HCF-1 binding motif."
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"Studies of the effects of BAP1 on cell proliferation have shown conflicting results, with some reporting that BAP1 suppresses cell proliferation, and others reporting that BAP1 enhances proliferation."
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"In cutaneous melanoma cell lines, however, stable over-expression of BAP1 promoted cell growth while knockdown of BAP1 suppressed cell proliferation with concomitant decrease of survivin, an anti-apoptotic protein [17]."
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"Concomitant Bap1 and Ezh2 loss reduced myeloid progenitor expansion, reduced the proportion of Mac1 + Gr1 + myeloid cells, restored erythroid differentiation (CD71 + Ter119 +) and decreased proliferation of Bap1 and Ezh2 deficient progenitors (XREF_FIG and XREF_SUPPLEMENTARY)."
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"BAP1 binds to HCF-1 in renal cancer cell lines. xref BAP1 binding was demonstrated through reciprocal immunoprecipitation experiments, and most BAP1 protein co-fractionated with HCF-1 by gel filtration chromatography. xref BAP1 binding to and co-fractionation with HCF-1 was also observed in orthotopic tumorgrafts in mice directly derived from surgically removed tumors of patients. xref Consistent with previous observations, xref immunoprecipitations of BAP1 and HCF-1 deplete BAP1 protein to a similar extent suggesting that most BAP1 is bound to HCF-1 (at least in cells reconstituted with BAP1). xref Binding to HCF-1 is important for BAP1-supression of cell proliferation. xref BAP1 reintroduction into two different BAP1-deficient ccRCC cell lines reduced cell growth. xref The inhibition of cell proliferation by BAP1 was compromised by disruption of the HCF-1 binding motif. xref Taken together these data suggest that BAP1 binding to HCF-1 is important for its tumor suppressor function in renal cancer."
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