IndraLab

Statements

UBD binds CYLD. 3 / 3
| 1 2
sparser
"Recent structural characterization of CYLD bound to Lys63-linked diubiquitin in the catalytic state and Met1-linked diubiquitin in both the pre-catalytic and catalytic states revealed that the His side chain is arranged in a catalytically competent orientation with either diubiquitin xref ."
27012468
reach
"Thus, the current structures of CYLD bound to diubiquitin do not provide an explanation of how phosphorylation controls Ub linkage cleavage."
27425610
sparser
"Structural comparison with the USP7-ubiquitin complex (PDB 5JTJ) and with the CYLD-diubiquitin K63 complex (PDB 3WXG) xref indicates that the IL-loop and the “distal” ubiquitin share a similar binding surface (Fig.  xref and Supplementary Figure  xref ), thus preventing substrate binding in the tetramer assembly."
30478318