IndraLab

Statements

Modified FOXO1 increases the amount of FOXO1. 11 / 11
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"Therefore, it is unlikely that the differential Foxo1 expression in antigen experienced T cells is caused by varying Foxo1 expression in precursor T cells."
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"In contrast, overexpression of FoxO1 inhibited the viability of MGCs and induced the expression of endogenous FoxO1."
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"In vitro model of DN, over-expression of FoxO1 induced the protein expression of FoxO1 and SERPINB1."
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"Our results showed that overexpression of WT FoxO1 stimulated endogenous FoxO1 expression and FoxO1 promoter activity, as well as elevation of apoptotic signals in MGCs (XREF_FIG and XREF_FIG)."
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"Accordingly, knockdown of FoxO1 expression using siRNA decreased FoxO1 protein levels and promoted cell growth significantly (XREF_FIG)."
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"Additionally, expression of the FOXO1 transcriptional target gene BIM, which is induced by activity withdrawal, was inhibited by overexpression of the dominant negative FOXO1 Ser249Ala mutant but not wildtype FOXO1, implying a critical role for FOXO1 Ser249 in endogenous Bim induction."
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"In addition, lentiviral mediated FOXO1 overexpression in the kidneys of diabetic mice considerably increased FOXO1 expression and activation, while decreasing proteinuria and renal pathological injury."
26902117
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"The expression of FOXO1 was increased by FOXO1 overexpression but reduced by miR-1269a mimic, and co-transfection with FOXO1 and miR-1269a could reverse these effects (P < 0.001, Fig."
32607060
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"Expression of FoxO1 (3A/LXXAA) mutant abolishes interaction between Sirt1 and FoxO1 and Sirt1 induced stimulation of FoxO1 mediated transcription."
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"As shown in the western blot, overexpression of WT FoxO1 significantly increased endogenous FoxO1 expression, whereas the DBD mutant had no effect (XREF_FIG)."
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"A western blot analysis indicated that FOXO1 expression was up-regulated by FOXO1 overexpression and silenced by siRNA-FOXO1."
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