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Zinc atom activates PSMD14. 2 / 2

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"We allowed these stalled proteasomes to accumulate under single-turnover conditions before reactivating Rpn11 by addition of Zn 2+ to sequester 1,10-phenanthroline away from the DUB active site."

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"In vitro , when Rpn11 is activated by addition of Zn 2+ but the 20S core proteases are blocked, deubiquitinated substrates stall and accumulate."

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IndraLab

Statements

Zinc atom activates PSMD14. 2 / 2

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