IndraLab

Statements

USP8 activates PRKN. 12 / 13
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"For instance, USP8 modulates parkin by selectively removing Lys6-linked chains, thus biasing the chains toward Lys48-linked chains that promote degradation."
37054910
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"USP8 KD also prevented Parkin KO DA neurons loss and normalized mitochondrial morphological defects, although it did not ameliorate Parkin climbing performance (XREF_FIG)."
30988163
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"H 2 S may upregulate the expression of deubiquitinating enzymes USP8 to antagonize the degradation of Parkin protein."
32477150
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"Only USP8 supports mitophagy by stabilizing the E3 ligase Parkin."
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"In contrast, USP8 promotes Parkin mediated mitophagy and agonists to USP8 could be developed as potential therapeutics."
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"The E3 ubiquitin ligase neuregulin receptor degradation protein 1 (Nrdp1) and the deubiquitination enzyme ubiquitin-specific protease 8 (USP8) counterbalance ubiquitin dynamics to direct Parkin action or its proteasomal degradation (10,11)."
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"Parkin is in turn regulated by several DUBs; USP8 promotes Parkin activity and mitophagy by removing the K6-linked ubiquitin chains, which prevent Parkin’s interaction with the phosphorylated ubiquitin and PINK1 [157], while USP15 and USP30 antagonize Parkin by removing ubiquitin chains from mitochondria, preventing the binding of mitophagy receptors [158,159]."
36552827
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"USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the Drosophila Brain and in Human Neurons."
37190052
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"Additionally, parkin availability depends on the persulfidation of ubiquitin specific peptidase 8 (USP8), a deubiquitinase, to prevent parkin degradation, promote parkin migration to damaged mitochondria, and initiate mitophagy [6]."
39728543
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"USP8 has been demonstrated to selectively remove K6-linked UB chains from Parkin and promote Parkin localization to depolarized mitochondria (80, 81)."
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"On the other hand, USP8 deubiquitinates and therefore activates Parkin, thus favoring mitophagy [ 8 ]."
31550441
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"In contrast, USP8 promotes parkin mediated mitophagy and thus agonists of this DUB could be developed XREF_BIBR."
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