IndraLab

Statements

USP14 activates cell cycle. 13 / 14
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"Furthermore , we examine cell cycle distribution by flow cytometry and find that inhibition of USP14 causes cell cycle arrest in G2 / M phase ."
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"It has been reported that USP14 expression was specifically upregulated in both lung adenocarcinoma cell lines and tumor tissues , and knockdown of USP14 expression significantly inhibited cell growth and cell cycle arrest in NSCLC cells12 ."
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"27 In this study, we have identified that USP14 promotes the cell cycle in prostate carcinoma cells by deubiquitination and stabilization of AR."
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"35 The AR dependent cell cycle arrest by inhibiting USP14 prompted us to investigate the interaction between USP14 and AR."
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"It has been shown that USP14 modulates levels of key cell cycle regulatory proteins whose dysregulation is expected to affect the cell cycle [XREF_BIBR]."
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"To investigate the molecular mechanism by which USP14 promotes cell cycle, we performed western blot to detect several key proteins that are associated with G1-S phase transition."
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"In addition, silencing USP14 expression with siRNA or stable expression of shRNA also caused G0/G1 cell cycle arrest (XREF_FIG), indicating that USP14 promotes G1-S transition in androgen responsive prostate cancer cells."
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"We confirmed that AR was highly expressed in the androgen responsive prostate cancer cells (LNcap cells) but was hardly detectable in the androgen-irresponsive prostate cancer cells (DU145 and PC3 cells) tested here (XREF_FIG), implying that the induction of cell cycle arrest by USP14 inhibition is AR dependent."
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"However, multi‐center‐based investigation is needed for further validation of its predictive value.It has been shown that silencing of USP14 could block the cell cycle progression and elicit caspase‐dependent apoptosis in MM cells.13 Also, inhibition of USP14 led to G0/G1 arrest by accelerating the ubiquitination and degradation of AR in prostate cancer cells."
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"USP14 and UCHL5 inhibitors suppress cell cycle progression."
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"Furthermore, changes in key cell cycle regulators induced by the manipulation of USP14 function also support the notion that AR is a key target for USP14 in the prostate cancer cells."
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"It has been reported that USP14 expression was specifically upregulated in both lung adenocarcinoma cell lines and tumor tissues, and knockdown of USP14 expression significantly inhibited cell growth and cell cycle arrest in NSCLC cells XREF_BIBR."
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"USP14 promotes cell cycle by upregulating key proteins associated with the G0/G1 to S phase transition."
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