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USP14 activates cell cycle. 22 / 23
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"Furthermore, in androgen-responsive prostate cancer cells, inhibiting the function of USP14 resulted in cell proliferation inhibition and cell cycle arrest at the G0/G1 phase, as USP14 could promote c[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"It has been reported that USP14 expression was specifically upregulated in both lung adenocarcinoma cell lines and tumor tissues, and knockdown of USP14 expression significantly inhibited cell growth and cell cycle arrest in NSCLC cells XREF_BIBR."
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"VSMC proliferation depends on G1 to S phase transition of the cell cycle; hence, we speculated that USP14 promotes cell cycle progression."
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"Furthermore , we examine cell cycle distribution by flow cytometry and find that inhibition of USP14 causes cell cycle arrest in G2 / M phase ."
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"We confirmed that AR was highly expressed in the androgen responsive prostate cancer cells (LNcap cells) but was hardly detectable in the androgen-irresponsive prostate cancer cells (DU145 and PC3 cells) tested here (XREF_FIG), implying that the induction of cell cycle arrest by USP14 inhibition is AR dependent."
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"Cell cycle distribution at G0/G1 was less in the USP14 group than in the control group (Fig. S1C, D), indicating that USP14 promotes cell cycle progression from the G1 to the S phase."
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"Furthermore, changes in key cell cycle regulators induced by the manipulation of USP14 function also support the notion that AR is a key target for USP14 in the prostate cancer cells."
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"35 The AR dependent cell cycle arrest by inhibiting USP14 prompted us to investigate the interaction between USP14 and AR."
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"It has been shown that USP14 modulates levels of key cell cycle regulatory proteins whose dysregulation is expected to affect the cell cycle [XREF_BIBR]."
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"For example, USP14 is related to the malignant transformation of hepatocytes and promotes hepatocellular carcinoma development by increasing cell proliferation, altering the cell cycle and reducing apoptosis [6]."
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"27 In this study, we have identified that USP14 promotes the cell cycle in prostate carcinoma cells by deubiquitination and stabilization of AR."
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"Recently, Liu et al. [9] identified 42 potential substrates of USP14, including CDK1 protein, indicating that USP14 might directly regulate cell cycle progression through CDK1."
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"Through flow cytometry, we demonstrated that USP14 knockdown arrested the cell cycle at the G2/M phase."
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"USP14 inhibition arrests the cell cycle at G2/M phase."
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"All these results suggested that USP14 was essential for cell cycle progression, and genetic or pharmacological inhibition of USP14 arrested the cell cycle at the G2/M phase."
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"USP14 and UCHL5 inhibitors suppress cell cycle progression."
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"In our study, we used MDA-MB-231 and MDA-MB-468 cells which expressed low level of AR, and inhibition of USP14 arrested the cell cycle at G2/M phase."
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"It has been reported that USP14 expression was specifically upregulated in both lung adenocarcinoma cell lines and tumor tissues , and knockdown of USP14 expression significantly inhibited cell growth and cell cycle arrest in NSCLC cells12 ."
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"USP14 promotes cell cycle by upregulating key proteins associated with the G0/G1 to S phase transition."
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"In addition, silencing USP14 expression with siRNA or stable expression of shRNA also caused G0/G1 cell cycle arrest (XREF_FIG), indicating that USP14 promotes G1-S transition in androgen responsive prostate cancer cells."
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"To investigate the molecular mechanism by which USP14 promotes cell cycle, we performed western blot to detect several key proteins that are associated with G1-S phase transition."
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"However, multi‐center‐based investigation is needed for further validation of its predictive value.It has been shown that silencing of USP14 could block the cell cycle progression and elicit caspase‐dependent apoptosis in MM cells.13 Also, inhibition of USP14 led to G0/G1 arrest by accelerating the ubiquitination and degradation of AR in prostate cancer cells."
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