IndraLab

Statements

BRAF binds TP53 and KRAS. 9 / 9
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"TP53, KRAS , and BRAF mutations were additionally independently associated with poor prognosis, although the association with BRAF and KRAS was restricted to MSI-negative tumours."
30042065
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"However, p53, B-Raf V600E and K-Ras G13D proved dispensable for drug’s cytotoxic activity, thus rendering 3-BrPA a powerful therapeutic tool for the successful management of urothelial bladder tumors carrying either wild-type or mutant p53, B-Raf or K-Ras oncogenic forms."
26198749
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"CRC molecular features including MSI, CIMP and mutations in BRAF , KRAS and TP53 were not associated with age-adjusted cRTL or cRTL:nRTL ratios (multivariate P>0.115 for all comparisons) (Table xref )."
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"TP53, BRAF, and KRAS mutations are associated with differential lncRNA expression."
29963224
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"For example, P53, KRAS, or BRAF mutations in metastatic colorectal cancer did not associate with bevacizumab-chemotherapy treatment outcome in metastatic colorectal cancer [ xref ]."
24340224
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"In multivariable analysis incorporating known clinicopathological prognostic factors, we showed that low overall mutation burden and mutations in KRAS, BRAF , and TP53 were independently associated with decreased relapse-free survival after colorectal cancer treated with curative intent."
30042065
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"In a larger subset of patients with mutated TP53 and KRAS as well as wt- BRAF , treatment with Cetuximab was associated with an increase in PFS [ xref ]."
34064974
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"Furthermore, mutations in p53, K-Ras and BRAF are associated with the neoplastic changes of IECs during the sporadic colon cancer development; BRAF and K-Ras mutations have been considered as prognostic markers for MSI ( xref )."
27110580
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"Multivariate analysis revealed that variant NOTCH3 was an independent prognostic factor for increased survival (hazard ratio 0.61, 95% confidence interval, 0.39-0.94; P = 0.03) besides poor prognostic factors associated with mutant TP53, KRAS, and BRAF, as well as amplified MYC."
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