Other Services

This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP47 activates math-33. 2 / 2

| 2

➶

reach

"Furthermore, depletion of these 22 DUBs in math-33 (tm3561) mutants revealed that depletion of T05H10.1, hereafter referred to as USP-47, caused synthetic lethality in the math-33 (tm3561) mutant by increasing embryonic lethality from 35% to 95% (XREF_FIG), and by increasing the lethality of a second probable null math-33 allele, ok2974, from 45% to 93%."

23209443

➶

reach

"We tested whether the major action of MATH-33 and USP-47 was to antagonize poly-ubiquitylation by asking whether compromising protein turnover could suppress the lethality and polarity defects of math-33 (tm3561); usp-47 (RNAi) worms."

23209443

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...