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USP11 activates resistance 5-Fu. 2 / 2
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eidos
"Taken together these data , we hypothesized that USP11 might mediate resistance to 5-Fu by inducing autophagy in colorectal cancer cells and verified the hypothesis in follow-up experiments ."

eidos
"USP11 promotes 5-Fu resistance through inducing autophagy dependent on VCP The above experimental results have confirmed that USP11 could not only mediate the resistance to 5-Fu , but also induce autophagy in colorectal cancer cells ."