IndraLab

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USP10 inhibits TP53. 25 / 33
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"Mechanistically, both of them promote cell proliferation via inhibiting the expression of USP10, which further decreases the stability of p53 [29,30]."
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"In response to DNA damage, USP10 translocates to the nucleus and deubiquitinates p53, and further prevents p53 from nuclear export and degradation [7] ."
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"Indeed, downregulation of USP10 decreases p53 stability and increases cancer cell proliferation XREF_BIBR, thus projecting a role as a tumor suppressor."
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"Expression of USP10 significantly suppressed c-Myc transcriptional activity in p53 wildtype and p53 -/- HCT116 cells, but the levels of USP10 mediated suppression in c-Myc target gene transcription in p53-null cells were partially reversed."
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"Hypoxic-induced circWSB1 can interact with ubiquitin-specific peptidase 10 (USP10) to reduce p53 stability mediated by USP10 and promote progression of breast cancer, making it a potential therapeutic[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Lin et al. showed that USP10 inhibits the occurrence and development of colon cancer by deubiquitinating SIRT6. xref Sun et al. found that USP10 inhibits the proliferation and metastasis of tumor cells by upregulating PTEN expression. xref Takayama et al. found that USP10 can inhibit P53 by deubiquitinating G3BP2. xref Yuan et al. found that USP10 can deubiquitinate TGF‐β to promote distant metastasis of hepatocellular carcinoma in Smad4‐positive patients. xref These investigations have demonstrated that USP10 has a key contribution to malignant tumors."
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"Association of USP10 with G3BP2 Inhibits p53 Signaling and Contributes to Poor Outcome in Prostate Cancer."
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"As a ceRNA, lnc-NR3C upregulated the activity of the USP10/p53 axis by sponging miR-129-5p, which inhibited the expression of USP10 (Fig. 8)."
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"Consistent with this notion, USP10 expression is frequently lost in renal cell carcinoma, and overexpression of USP10 suppresses cell transformation and tumorigenesis in a p53 dependent fashion."
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"It also binds USP10, a key p53 regulator, reducing p53 stability and its anti-cancer functions."
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"As a deubiquitinase, USP10 prevents the target protein p53 from interacting with ubiquitin, blocking the polyubiquitination and subsequent degradation of p53 [33]."
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"It also binds USP10, a key p53 regulator, reducing p53 stability and anti-cancer functions."
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"Usp10 overexpression abolished the estrogen mediated regulation of p53 and the downstream transcriptional gene p21."
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"USP10 can deubiquitinate cytoplasmic p53 and inhibit MDM2-mediated p53 nuclear export and degradation."
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"Coexpression of WT USP10 with Mdm2 reversed Mdm2 induced cytoplasmic translocation of p53."
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"The research by Yuan et al. demonstrated that USP10 inhibits cancer cell proliferation in wild-type p53 cells, but promotes tumorigenesis in a mutant p53 background (Yuan et al., 2010)."
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"USP10 can interact with G3BP2 to block P53 signaling, leading to a poor prognosis in PC (94)."
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"In line with this study, here, we also found that overexpression of USP10 downregulated p53, caspase-1, and Bax, while upregulated Bcl-xl in DOX-resistant thyroid cancer cells."
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"Indeed, USP10 depletion attenuates DNA damage induced stabilization of p53, an effect that was rescued by overexpression of wild-type USP10 but not by mutant USP10 lacking ATM phosphorylation sites."
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"USP10 suppresses tumor cell growth in cells with wild-type p53."
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"Downregulation of p53 abolished the inhibitory effect of USP10 on tumor growth (XREF_FIG and data not shown), confirming that USP10 inhibits cancer cell growth by stabilizing p53."
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"For example, USP10 can interact with G3BP2 (Ras GTPase-activating protein-binding protein 2) to block p53 signalling and, thus, contributes to a poor prognosis in prostate cancer [71] ."
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"USP10 can interact with G3BP2 to block p53 signaling and subsequently contributes to a poor prostate cancer prognosis [ 50 ] ."
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"The association of USP10 with G3BP2 suppresses p53 signalling which correlates to a poor prognosis in prostate cancer, highlighting an oncogenic role of USP10 in prostate cancer via G3BP2 [XREF_BIBR]."
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"For example, USP10 regulates Notch signaling pathway in the endothelium [23]; USP10 protects against cerebral ischemia injury by attenuating inflammation and apoptosis through inhibiting the TAK1 signaling pathway [8]; Interaction of USP10 and G3BP2 blocks p53 signaling and results in poor prognosis in prostate cancer [24]; Wu-5, which is an inhibitor of USP10, enhances crenolanib-induced FLT3-ITD-positive AML cell death by suppressing FLT3 and AMPK signaling pathways [25]."
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