IndraLab

Statements

USP10 inhibits TP53. 17 / 25
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"Expression of USP10 significantly suppressed c-Myc transcriptional activity in p53 wildtype and p53 -/- HCT116 cells, but the levels of USP10 mediated suppression in c-Myc target gene transcription in p53-null cells were partially reversed."
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"In addition, USP10 suppresses the tumour cell growth in cells with wild-type p53, and USP10 expression is down-regulated in a high percentage of clear cell carcinomas known to have few p53 mutations [108]."
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"It also binds USP10, a key p53 regulator, reducing p53 stability and its anti-cancer functions."
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"Indeed, USP10 depletion attenuates DNA damage induced stabilization of p53, an effect that was rescued by overexpression of wild-type USP10 but not by mutant USP10 lacking ATM phosphorylation sites."
20144755
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"Association of USP10 with G3BP2 Inhibits p53 Signaling and Contributes to Poor Outcome in Prostate Cancer."
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"The research by Yuan et al. demonstrated that USP10 inhibits cancer cell proliferation in wild-type p53 cells, but promotes tumorigenesis in a mutant p53 background (Yuan et al., 2010)."
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"For example, USP10 regulates Notch signaling pathway in the endothelium [23]; USP10 protects against cerebral ischemia injury by attenuating inflammation and apoptosis through inhibiting the TAK1 signaling pathway [8]; Interaction of USP10 and G3BP2 blocks p53 signaling and results in poor prognosis in prostate cancer [24]; Wu-5, which is an inhibitor of USP10, enhances crenolanib-induced FLT3-ITD-positive AML cell death by suppressing FLT3 and AMPK signaling pathways [25]."
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"Usp10 overexpression abolished the estrogen mediated regulation of p53 and the downstream transcriptional gene p21."
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"The association of USP10 with G3BP2 suppresses p53 signalling which correlates to a poor prognosis in prostate cancer, highlighting an oncogenic role of USP10 in prostate cancer via G3BP2 [XREF_BIBR]."
30595162
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"USP10 can interact with G3BP2 to block p53 signaling and subsequently contributes to a poor prostate cancer prognosis [ 50 ] ."
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"Mechanistically, both of them promote cell proliferation via inhibiting the expression of USP10, which further decreases the stability of p53 [29,30]."
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"USP10 can deubiquitinate cytoplasmic p53 and inhibit MDM2-mediated p53 nuclear export and degradation."
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"Consistent with this notion, USP10 expression is frequently lost in renal cell carcinoma, and overexpression of USP10 suppresses cell transformation and tumorigenesis in a p53 dependent fashion."
20531303
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"Coexpression of WT USP10 with Mdm2 reversed Mdm2 induced cytoplasmic translocation of p53."
20096447
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"Downregulation of p53 abolished the inhibitory effect of USP10 on tumor growth (XREF_FIG and data not shown), confirming that USP10 inhibits cancer cell growth by stabilizing p53."
20096447
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"Indeed, downregulation of USP10 decreases p53 stability and increases cancer cell proliferation XREF_BIBR, thus projecting a role as a tumor suppressor."
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"It also binds USP10, a key p53 regulator, reducing p53 stability and anti-cancer functions."
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