IndraLab

Statements

SQSTM1 binds USP10. 23 / 23
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sparser
"Moreover, research shows that USP10 interacts with p62 and augments p62-dependent ubiquitinated protein aggregation and aggresome formation, which inhibit proteasome activity [ xref ]."
35269473
sparser
"These ubiquitinated proteins bind to p62 and USP10, and the formed aggregates inhibit proteasome activity to further increase the amount of ubiquitinated proteins."
30469013
sparser
"These results suggested that protein–protein interaction between p62 and USP10 is not necessary for the formation of p62-bodies in dopamine-treated cells."
34838592
sparser
"These results suggested that USP10 interacts with p62 to increase the amount of pp62-S349 and that pp62-S349 increased by USP10 reduces the degradation of Nrf2 in dopamine-treated cells."
34838592
reach
"To promote protein aggregation and aggresome formation, USP10 interacted with p62, and they cooperatively inhibited caspase-3-associated cell death."
30469013
reach
"These results suggested that multiple interactions between USP10 and p62 are required for maximum aggresome promoting activity of USP10."
30469013
sparser
"To promote protein aggregation and aggresome formation, USP10 interacted with p62, and they cooperatively inhibited caspase-3-associated cell death."
30469013
reach
"Thus, we examined whether USP10 interacts with p62."
30469013
sparser
"The immunoprecipitation assay indicated that endogenous p62 interacted with endogenous USP10 together with previously known p62 interactors HDAC6 or dynein ( xref , xref ), both of which are important for aggresome formation ( xref A)."
30469013
sparser
"Interaction of USP10 with p62 promoted protein aggregation and aggresome formation ( xref )."
30469013
sparser
"USP10 interacts with the ubiquitin receptor p62 and the interaction augments p62-dependent ubiquitinated protein aggregation and aggresome formation, thereby cooperatively inhibiting apoptosis ( xref )."
33133065
sparser
"Thus, we examined whether USP10 interacts with p62."
30469013
sparser
"P62 interacted with USP10 in SH-SY5Y cells ( xref A ), but USP10 hardly colocalized with the p62-body in cells treated with dopamine ( xref , C and D )."
34838592
sparser
"USP10 interacts with P62, and this interaction enhances p62-dependent ubiquitination protein aggregation and aggregator formation [52] ."
35627217
reach
"Given that USP10 96-798 but not USP10 1-214 interacts with p62 (XREF_FIG C and 4D), these results also suggested that USP10 interaction with p62 induces large p62 aggregates and aggresomes."
30469013
sparser
"USP10 interacted with the ubiquitin receptor p62 and the interaction augmented p62-dependent ubiquitinated protein aggregation and aggresome formation, thereby cooperatively inhibiting apoptosis."
30469013
sparser
"Analysis using USP10 deletion mutants showed that both N- and C-terminal regions of USP10 interact with p62 and that these two regions are required for maximum aggresome-promoting activity ( xref F)."
30469013
reach
"The immunoprecipitation assay indicated that endogenous p62 interacted with endogenous USP10 together with previously known p62 interactors HDAC6 or dynein, both of which are important for aggresome formation (XREF_FIG A)."
30469013
sparser
"Given that USP10 96−798 but not USP10 1−214 interacts with p62 ( xref C and 4D), these results also suggested that USP10 interaction with p62 induces large p62 aggregates/aggresomes."
30469013
sparser
"These results suggested that multiple interactions between USP10 and p62 are required for maximum aggresome-promoting activity of USP10."
30469013
sparser
"The interaction between USP10 and p62 promotes aggresome formation and protects cells from apoptosis induced by the accumulation of ubiquitinated proteins [ xref ]."
33919439
sparser
"USP10 interacted with the Nrf2 activator p62, increased the phosphorylation of p62, increased the interaction of p62 with the Nrf2 inhibitor Keap1, and stimulated Nrf2 antioxidant transcriptional activity."
34838592
sparser
"P62 interacted with USP10 in cells without dopamine treatment, and the interaction was slightly reduced by dopamine treatment."
34838592