IndraLab

Statements

USP1 inhibits cellular senescence. 5 / 5
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"These results suggest that senescence compromised cancer cells expressing low levels of USP1 or treatment of cancer cells expressing high levels of USP1 with USP1 inhibitors may be more susceptible to[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Usp1 knockdown promotes senescence and reduces tumor growth in vivo."
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"Moreover, USP1 depletion increases oncogene-induced senescence and plays a pivotal role in protecting genomic instability by preventing FANCD2-Ub aberrant aggregation (12)."
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"In our human fibroblast senescence model, TAp63 upregulation was absent, indicating that acute loss of USP1 function likely produces qualitatively different senescence responses depending on cell type[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, in addition to this opposition to activate and monoubiquitinate FANCD2/I, USP1 deubiquitination of FANCI has also been associated with promoting core complex recruitment to the site of DNA da[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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