IndraLab

Statements

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"Moreover, hematoxylin and eosin and Picrosirius red staining of heart sections indicated that compared with those of their USP10‐Flox littermates, hearts from USP10‐CKO mice developed significant cardiomyocyte hypertrophy and fibrosis in the interstitial and perivascular spaces (Figure  xref through xref )."
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"In parallel, the mRNA levels of CH‐ and fibrosis‐related genes, including Anp, Bnp, Myh7, collagen Iα, collagen III, and Ctgf, were markedly increased in the hearts of USP10‐CKO mice compared with those in the hearts of USP10‐Flox controls (Figure  xref )."
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"Furthermore, the USP10‐CKO mice exhibited significantly increased LVEDd and LVESd values and decreased fractional shortening% and ejection fraction values compared with USP10‐Flox controls (Figure  xref through xref )."
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"Subsequently, USP10‐Flox and USP10‐CKO mice were subjected to AB surgery, and cardiac parameters were evaluated."
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"As shown in Figure  xref , the ratios of heart weight (HW) to body weight (BW) increased in USP10‐CKO mice compared with USP10‐Flox group at 4 weeks after AB surgery (Figure  xref )."
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"Western blotting results demonstrated that phosphorylation levels of Akt, GSK3β, mTOR, and p70‐S6K were significantly increased in hypertrophic hearts in USP10‐CKO mice compared with those in USP10‐Flox controls in response to AB surgery (Figure  xref )."
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