IndraLab

Statements

Snail1 inhibits CYLD. 4 / 4
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"Since the expression of CYLD is transcriptionally repressed by Snail1 22, and downregulation of CYLD results in an increase in RIP1 in melanoma cells, we examined whether ERK1/2 mediated expression of RIP1 is related to suppression of CYLD by Snail1."
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"Clinical relevance of Snail1 induced CYLD repression."
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"Our findings indicate that after malignant transformation, constitutively high ERK activity and Snail1 expression allow melanoma cells to permanently exploit transcriptional repression of CYLD and activation of BCL-3 to acquire a more aggressive phenotype."
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"Conversely, transient transfection of a Snail1 expression construct completely repressed CYLD promoter activity (XREF_FIG)."
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