IndraLab

Statements

Pyraclofos activates KCNC1. 4 / 4
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"FSIs are specifically adapted to fast firing by the expression of a unique selection of ion channels including rapid kinetics voltage‐activated potassium channel Kv3.1 subtype (Espinosa et al . xref , Gu et al . xref , Yanagi et al . xref ), and the voltage‐activated sodium Nav1.1 channels that have recently been suggested as a therapeutic target for cognitive disorders in schizophrenia (Jensen et al . xref )."
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"The rapid voltage-dependent activation/deactivation characteristics of Kv3.1 facilitate high firing rates in cells that express these channels."
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"To address this issue, Mishina et al. developed chimeric VSDs (Ci-VSP-Kv3.1 VSD chimeras) by transplanting homologous motifs from the tetrameric voltage-activated potassium channel, Kv3.1, to the monomeric CiVSD [136]."
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"The Shaw-like voltage-activated potassium channel Kv3.1 is expressed in neurons that generate rapid trains of action potentials."
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