IndraLab

Statements

Pyraclofos activates KCNC1. 5 / 5
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"The rapid voltage-dependent activation/deactivation characteristics of Kv3.1 facilitate high firing rates in cells that express these channels."
33828309
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"To address this issue, Mishina et al. developed chimeric VSDs (Ci-VSP-Kv3.1 VSD chimeras) by transplanting homologous motifs from the tetrameric voltage-activated potassium channel, Kv3.1, to the monomeric CiVSD [136]."
29250483
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"Here, we transplanted homologous amino acid motifs from the tetrameric voltage-activated potassium channel Kv3.1 to the monomeric VSD of Ciona intestinalis voltage-sensitive phosphatase (Ci-VSP) to explore which portions of Kv3.1 subunits depend on the tetrameric structure of Kv channels and which properties of Kv3.1 can be transferred to the monomeric Ci-VSP scaffold."
22947928
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"FSIs are specifically adapted to fast firing by the expression of a unique selection of ion channels including rapid kinetics voltage‐activated potassium channel Kv3.1 subtype (Espinosa et al . xref , Gu et al . xref , Yanagi et al . xref ), and the voltage‐activated sodium Nav1.1 channels that have recently been suggested as a therapeutic target for cognitive disorders in schizophrenia (Jensen et al . xref )."
27364459
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"The Shaw-like voltage-activated potassium channel Kv3.1 is expressed in neurons that generate rapid trains of action potentials."
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