IndraLab

Statements

OTULIN binds Trim14. 4 / 4
| 4
sparser
"The specificity of the HOIP PUB-OTULIN interaction stems from a binding preference of the HOIP PIM pocket for internal PIMs in contrast to the C-terminal PIM of p97/VCP [ xref , xref ]."
33288901
sparser
"Mapping analysis showed that the N‐terminus of OTULIN bound to the PUB domain in HOIP."
26503766
sparser
"Full-length OTULIN bound the PUB domain with a similar affinity as the OTULIN stretch from aa 45 to aa 73 (Kd FL  = 294 nM versus Kd 45–73  = 440 nM), suggesting that this region contains the complete[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24726327
sparser
"While the interaction of the Rnf31 PUB domain with the p97 C-terminal peptide is only ∼50 μM, the DUB OTULIN binds this PUB domain with a dissociation constant ∼300 nM, indicating that this mode of binding can facilitate a wide range of specificities [ xref ]."
28819009