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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

MDM2 bound to STAT5 inhibits TP53. 1 / 1

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"Therefore, we have discovered a surprising role and its related mechanism for MDM2 in stabilizing STAT5 in T cells.Given that MDM2 interacts with p53 and mediates p53 degradation in tumor cells , we have demonstrated that MDM2 can regulate T survival and function in the absence of p53."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...