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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

SsTx inhibits KCNQ4. 2 / 2

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"In addition, the Hill slope is 1.18 +/- 0.03 for inhibition of KCNQ4 by SsTx (XREF_FIG), and thus multiple SsTx molecules could interact with positive synergy to inhibit the channel."

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"Given that KCNQ4 is important in the regulation of pulmonary vascular tone, and blocking KCNQ4 increases the isometric tension of interlobular arteries, we hypothesized that SsTx may contribute to the vasospasm by inhibiting the KCNQ4 channel as reported in clinical cases of centipede envenomation."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...