IndraLab

Statements

SERPB12 activates USP14. 4 / 4
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reach
"SERPB12 stimulated USP14 but not UCHL5 activity."
30045019
reach
"SLFN12 or SERPB12 overexpression increases expression of the complementary deubiquitylases USP14 and UCHL5 in vitro, and SERPB12 stimulates USP14 deubiquitylase activity."
30045019
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"Moreover, when we mixed purified SERPB12 with each of these two purified deubuiquitylases in vitro, SERPB12 stimulated the DUB activity of USP14 (XREF_FIG) but not UCHL5 (XREF_FIG)."
30045019
reach
"Since both deubiquitylases have more substantial activity when proteasome bound in vivo than in isolation, whether SERPB12 stimulates proteasomally bound USP14 activity in vivo or competes for the USP14 proteasomal binding site awaits further study."
30045019