IndraLab

Statements

GATD3B decreases the amount of CYLD. 3 / 3
| 3
reach
"In T cell acute lymphoblastic leukemia (T-ALL), CYLD expression is repressed by the Notch and Hes1 pathway to promote persistent IKK activation and cell survival [XREF_BIBR]."
21119682
reach
"To test whether the Notch pathway and specifically Hes1 was directly repressing CYLD transcription, we used the Genomatix software to identify putative Hes1 binding sites, and found three distinct N-box consensus sites in the promoter and 5 ' UTR of the CYLD transcriptional start site (XREF_FIG, denoted as PRO1 and PRO2)."
20832754
reach
"A significant portion of these effects can be attributed to the suppression of CYLD expression by Hes1."
20832754