IndraLab

Statements

Cholesterol activates KCNMA1. 13 / 13
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"Sequestration or depletion of membrane cholesterol with nystatin or methyl-beta-cyclodextrin reduced the internalization of SLO negative GAS but had little effect in further reducing the relatively inefficient internalization of SLO positive GAS."
21325037
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"To verify that the loss of host cell membrane integrity was due to pore formation by SLO, infections were also performed with cells treated with the cholesterol depleting agent methyl-beta-cyclodextrin (MbetaCD), which blocks pore formation."
26059530
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"At physiological Ca 2+ i and voltages, cholesterol and PIP 2 reduce and increase slo1 channel activity, respectively."
36988883
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"BK channels expression and activity are also modulated by cholesterol , and the reports suggest tissue and cell-specific effects ( Wu et al ., 2013 ) ."
34177597
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"We found that membrane cholesterol modulates basal function, as well as the ethanol sensitivity of the BK channel."
22140451
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"In the case of beta1 subunit containing BK channels, the similar ability of cholesterol and ent-cholesterol to enhance BK channel function may hold the key to unraveling the precise mechanism by which both steroids blunt alcohol induced BK channel inhibition and the resulting cerebral artery constriction (XREF_FIG - XREF_FIG)."
27565113
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"Furthermore, kinetic analysis showed that cholesterol 's effect on single channel activity parameters (such as open and closed times) mirror that of ethanol, indicating that cholesterol and ethanol may target common hslo channel dwelling states."
22140451
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"As discussed previously, differences in the cis/trans K + gradient used likely contribute to explain the discrepancies on cholesterol modulation of BK channel unitary conductance between the different studies."
21149543
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"Smith-Lemli-Opitz syndrome (SLO) is caused by abnormal cholesterol biosynthesis."
22566357
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"The reduction of KCa1.1 protein by cholesterol enrichment can be reversed by proteasome inhibition with lactacystin or the lysosome inhibition with bafilomycin A1, suggesting that cholesterol enrichment induced BK channel reduction involved protein degradation."
24260325
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"Both anti-SLO antibodies and cholesterol reversed the suppressive effect of SLO on neutrophil oxidative burst in dose dependent manners."
26635795
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"Smith-Lemli-Opitz syndrome (SLO) is caused by inherited enzymatic deficiency of 7-dehydrocholesterol-delta7-reductase and resultant cholesterol deficiency."
9714007
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"Modulation of BK channel pharmacology by cholesterol."
22584144