IndraLab

Statements

Cholesterol activates KCNMA1. 22 / 22
| 1 21
eidos
"BK channels expression and activity are also modulated by cholesterol , and the reports suggest tissue and cell-specific effects ( Wu et al ., 2013 ) ."
34177597
reach
"Furthermore, kinetic analysis showed that cholesterol 's effect on single channel activity parameters (such as open and closed times) mirror that of ethanol, indicating that cholesterol and ethanol may target common hslo channel dwelling states."
22140451
reach
"Sequestration or depletion of membrane cholesterol with nystatin or methyl-beta-cyclodextrin reduced the internalization of SLO negative GAS but had little effect in further reducing the relatively inefficient internalization of SLO positive GAS."
21325037
reach
"As discussed previously, differences in the cis/trans K + gradient used likely contribute to explain the discrepancies on cholesterol modulation of BK channel unitary conductance between the different studies."
21149543
reach
"Reduction in Po by cholesterol is ablated by the Y450F mutation, suggesting that Y450 participates in cholesterol modulation of slo1 channel activity [24]."
| PMC
reach
"On the other hand, in compensation to the inhibitory action of cholesterol on slo1 channels in planar lipid bilayers, cholesterol enrichment of MCA SM cells has been reported to increase BK channel activity in male rats [25]."
| PMC
reach
"In the case of beta1 subunit containing BK channels, the similar ability of cholesterol and ent-cholesterol to enhance BK channel function may hold the key to unraveling the precise mechanism by which both steroids blunt alcohol induced BK channel inhibition and the resulting cerebral artery constriction (XREF_FIG - XREF_FIG)."
27565113
reach
"Modulation of BK channel pharmacology by cholesterol."
22584144
reach
"At physiological Ca 2+ i and voltages, cholesterol and PIP 2 reduce and increase slo1 channel activity, respectively."
36988883
reach
"To verify that the loss of host cell membrane integrity was due to pore formation by SLO, infections were also performed with cells treated with the cholesterol depleting agent methyl-beta-cyclodextrin (MbetaCD), which blocks pore formation."
26059530
reach
"Chemistry-driven approaches focused on elucidating the interaction between type Π lipids (cholesterol being one example) and proteins whereas biological studies focused on understanding how BK channel modulation by cholesterol contributes to cell physiology and pathology, as discussed elsewhere [17]."
36988883
reach
"Indeed, cell cholesterol has been shown to modulate BK channel function, this modulation exhibiting tissue-specific effects on BK currents [17, 18]."
36988883
reach
"Smith-Lemli-Opitz syndrome (SLO) is caused by abnormal cholesterol biosynthesis."
22566357
reach
"Cholesterol modulation of BK channel function long predates that of PIP and was framed into lipid versus protein theories of ligand action, as succinctly discussed below."
36988883
reach
"Both anti-SLO antibodies and cholesterol reversed the suppressive effect of SLO on neutrophil oxidative burst in dose dependent manners."
26635795
reach
"Moreover, cholesterol enrichment of mouse and rat middle cerebral artery SM cells using methyl-β-cyclodextrin resulted in BK channel activation [65]."
36988883
reach
"3.2 Cholesterol Modulation of Homomeric Slo1 Channels."
36988883
reach
"Remarkably, this requirement was divalent-specific: in the absence of Ca , BK channel-activating concentrations of Mg (10 mM) did not support cholesterol-induced inhibition of BK current [69]."
36988883
reach
"These findings underscore the importance of physical proximity of ligand-sensing motifs for cholesterol modulation of slo1 channels."
36988883
reach
"The reduction of KCa1.1 protein by cholesterol enrichment can be reversed by proteasome inhibition with lactacystin or the lysosome inhibition with bafilomycin A1, suggesting that cholesterol enrichment induced BK channel reduction involved protein degradation."
24260325
reach
"We found that membrane cholesterol modulates basal function, as well as the ethanol sensitivity of the BK channel."
22140451
reach
"Smith-Lemli-Opitz syndrome (SLO) is caused by inherited enzymatic deficiency of 7-dehydrocholesterol-delta7-reductase and resultant cholesterol deficiency."
9714007