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TP53 phosphorylates STAT3. 17 / 17
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"We found that the inhibition of STAT3 phosphorylation by AG490 down-regulated mutp53 in both cell lines ( xref ) and that also STAT3 silencing by specific siRNA reduced mutp53 expression level in U373 and Panc1 cells ( xref )."
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"TP53 activates the phosphorylation of Stat3 [90], inducing the overexpression of CCND1 allowing damaged DNA to be replicated by antagonizing the checkpoint-induced cell cycle arrest and disturbing DNA replication [91]."
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"Similar to previous studies, we observed that wild-type p53 inhibited phosphorylation of STAT-3 in response to OSM, and mutant p53 promoted the phosphorylation of STAT-3."
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"These observations suggested that p53 or a p53 downstream gene product may directly or indirectly inhibit STAT3 phosphorylation or upstream activators of STAT3 such as JAK2."
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"Upon expression of various p53 hotspot missense mutants in TP53 −/− H1299 and HCT116 cells, some p53 mutants augmented Stat3 phosphorylation."
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"We found that, compared to the empty vector (EV), p53 silencing (sip53) rescued STAT3 phosphorylation in apigenin treated BC3 cells, confirming the role of p53 in STAT3 inhibition."
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"Although the correlation of p-STAT3 staining in clinical prostate cancer specimens with EAF2 downregulation and/or nuclear p53 staining was not strong, it is consistent with our hypothesis that defects in EAF2 and/or p53 signaling can enhance STAT3 phosphorylation and promote prostate carcinogenesis."
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"One explanation for this discrepancy proposes that additional mutations in p53 in human cancer cell lines mediate constitutive phosphorylation of Stat3, as seen in other tumor cells (Lin et al., 2002)[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, in prostate cancer cells, inactivation of both ELL-associated factor 2 (EAF2) and p53 can enhance STAT3 phosphorylation and drive tumorigenesis, and this regulation of STAT3 phosphorylation by EAF2 and/or p53 may involve multiple mechanisms [ xref ]."
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"Contact with PC cells favors EC proliferation and production of angiogenic and angiocrine factors, which are boosted by PC expression of IL30, that feeds autocrine loops, mediated by IGF1, EDN1, ANG and CXCL10, and promotes vascular budding and inflammation, via phosphorylation of multiple signaling proteins, such as Src, Yes, STAT3, STAT6, RSK1/2, c-Jun, AKT and, primarily CREB, GSK-3alpha/beta, HSP60 and p53."
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"Additionally, bavachin upregulates the expression of p53 by downregulating phosphorylated signal transducer and activator of transcription 3 (p-STAT3)."
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"SF predominately induced phosphorylation of STAT3 (pSTAT3) and, to a lesser degree, p53, compared to serum ( Figure 3A )."
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"In this study, the data showed that p53 bound to STAT3 and highly expressed circ-DNMT1 or p53 promoted the phosphorylation of JAK2 and STAT3."
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"Finally, 11 dose-independently induced apoptosis and autophagy, activated p53, reduced ROS production, and reduced STAT3 phosphorylation in KSHV PEL cells [78]."
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"STAT3 phosphorylation by p53 knockdown in C4-2 cells is consistent with a previous finding that p53 transfection inhibited STAT3 phosphorylation at Tyr705 in prostate cancer cells XREF_BIBR."
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"EAF2 knockdown in prostate cancer cells and knockout in normal mouse prostate induced STAT3 (Tyr705) phosphorylation, suggesting that EAF2 is a repressor of STAT3 signaling and that p53 is insufficient to fully repress the phosphorylation of STAT3 in the absence of EAF2."
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"TP53 R248Q activates the phosphorylation of Stat3 [ xref ], inducing the overexpression of CCND1 allowing damaged DNA to be replicated by antagonizing the checkpoint-induced cell cycle arrest and disturbing DNA replication [ xref ]."
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