IndraLab

Statements

Proteasome binds USP14 and 26S. 3 / 3
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"As USP14 and Ubp6 has been shown to be activated 300-fold upon binding to the proteasome, participating in the stepwise removal of ubiquitin and sparing it from proteasomal degradation, and that a loss of USP14 activity results in reduced levels of free ubiquitin, we next analyzed free ubiquitin levels in CD4 + T cells during aging, to evaluate whether increased USP14 activity associated with the 26S proteasome, impacts levels of free cellular ubiquitin."
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"The binding of USP14 to the 26S proteasome was monitored by western blotting using an antibody against USP14 (Bethyl Laboratories, Inc)."
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"(B) The effect of USP14 aptamers on USP14 binding to the 26S proteasome was determined by immunoblotting after pulldown assays."
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