IndraLab

Statements

Notch increases the amount of TP53. 9 / 9
| 9
reach
"Notch ligand mediated activation dramatically decreased pMDM2 Ser260 without altering total MDM2 levels, and markedly increased p53 protein levels (XREF_FIG)."
31227645
reach
"To further examine the ability of Notch signaling to induce p53 expression, we transduced and sorted AML cells in vitro and found significantly increased levels of p53 protein, along with increased cleaved caspase3 and PARP1 (XREF_FIG)."
23359069
reach
"Re-expression of p53 (wt) in p53 (null) cells restored the inhibition of proliferation by activated Notch."
18049480
reach
"Our data indicate that the Notch pathway positively regulates p53 activation and induces transcription of the p53 target genes MDM2 and PHLDA3."
34352404
reach
"Moreover, we observed that the constitutively active form of Notch (extracellular domain-deprived Notch mutant, Notch-DeltaE) could upregulate the expression of p16 , p53, γH2AX, HES1, and HEY1, which could be reversed by RO4929097, MYL3 overexpression, dynasore, and clathrin knockdown (Fig. 5i)."
37794006
reach
"To directly investigate whether Notch target genes can induce p53 transcription, we cotransfected the p53 reporter plasmid and plasmids encoding individual Hey and Hes proteins into MuSCs."
30244867
reach
"Chemical inhibition of Notch signaling in both human and mouse keratinocytes did not reduce the expression of p53 at the protein or mRNA level either before or after transduction with the reprogramming factors (XREF_FIG and XREF_SUPPLEMENTARY)."
24952596
reach
"In fact, upregulation of p53 expression by Notch activation, at the level of gene transcription, has also been observed in glioma cells 80, but sustained Notch signalling in this case is important for survival 50."
19609265
reach
"Thus, IKAROS may not trigger Tp53 repression, but the increase of H3K79 methylation and the ' additive effect ' observed in Ik Null / OP9-DL1 suggest that, by controlling H3K79me2 levels, IKAROS prevents the NOTCH dependent induction of Tp53 transcriptional overexpression, which is likely linked to a variation in the control of transcriptional elongation."
33770102