A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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sparser
"We found no evidence that MDM2 gene SNP309 or p53 gene SNP72 is associated with an increased risk for, or accelerated formation of, diffuse-large B-cell lymphoma in men or women of central European Caucasian ethnicity."
sparser
"We found an association of p53 codon72 arginine and MDM2 SNP309 GG genotype with different clinical and histological grades, human papillomavirus (HPV) infection, and age at the time of diagnosis of cervical cancer."
sparser
"The present meta-analysis indicated that the 2 gene polymorphism loci MDM2 SNP309 and p53 Arg72Pro were significantly associated with the HCC risk."
sparser
"We analyzed the interaction of TP53 R72P and MDM2 SNP309 SNPs in relationship to outcome in patients with myelodysplastic syndromes (MDS)."
sparser
"In contrast with several case-series studies, the interaction between MDM2 SNP309 and TP53 mutation was not statistically significant in our LFS family cohort."
sparser
"In conclusion, in this large collaborative study, we did not find an association of MDM2 SNP309 and TP53 R72P, separately or in interaction, with breast cancer."
sparser
"Although the contribution of MDM2 SNP309 to cancer incidence became substantially greater when both germ-line p53 and gender were incorporated into the model, the interaction between MDM2 SNP309 and p53 mutations was not statistically significant in our analyses."
sparser
"There were twelve studies that investigated the interaction of MDM2 SNP309 and p53 codon72 polymorphism on cancer risk; however, only six studies [ xref , xref , xref , xref , xref , xref ] offered detailed data (Table xref )."
sparser
"In the present study, an analysis of 102 cases that were not type II demonstrated a significant interaction between the MDM2 SNP309 and TP53 Arg72Pro polymorphism with endometrial cancer risk."
sparser
"In this meta-analysis, we pooled the eligible studies for association of MDM2 SNP309 and p53 Arg72Pro on tumor risk."
sparser
"The relative risk to develop osteosarcomas and the overall survival associated to TP53 Arg72Pro and MDM2 SNP309 polymorphisms were investigated in 201 patients."
sparser
"A number of studies have investigated associations between SNPs of MDM2 SNP309 and p53 codon 72 and SCCHN risk, but the results are controversial [ xref , xref , xref – xref ]."