IndraLab

Statements

Tamoxifen activates KCNMA1. 6 / 6
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"In outside-out patches, ethylbromide tamoxifen increased BK channel NP (o) with an EC (50) value of 1 microM."
11961128
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"The xenoestrogen, tamoxifen, and the endogenous steroid hormone 17beta-estradiol were also found to activate the BK channel in a beta1- dependent manner."
27238261
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"At the single-channel level, tamoxifen significantly increased the open probability of the BK channel by 46.2 +/- 10.1% (n = 4) without changing its unitary conductance."
17164406
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"Patch clamp study revealed the characteristics of aging on MaxiK channel function in mesenteric arteries, mainly including (a) decrease of iberiotoxin sensitive whole-cell K (+) current, (b) decrease of open probability and Ca (2+)/voltage sensitivity of single MaxiK channel, and (c) reduction of tamoxifen induced MaxiK activation."
24347614
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"It has been shown that Tamoxifen, which is an agonist of estrogen receptors that is widely used for breast cancer therapy, also activates the BK channel, but is at least 10 times more potent than E2, causing a reversible and fast effect at concentrations as low as 0.1 muM."
25346693
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"Ethylbromide tamoxifen did not increase BK channel NP (o) in cell attached or inside-out patches; however, subsequent addition of equimolar tamoxifen did."
11961128