IndraLab

Statements

Tamoxifen activates KCNMA1. 8 / 9
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"In outside-out patches, ethylbromide tamoxifen increased BK channel NP (o) with an EC (50) value of 1 microM."
11961128
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"At the single-channel level, tamoxifen significantly increased the open probability of the BK channel by 46.2 +/- 10.1% (n = 4) without changing its unitary conductance."
17164406
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"Patch clamp study revealed the characteristics of aging on MaxiK channel function in mesenteric arteries, mainly including (a) decrease of iberiotoxin sensitive whole-cell K (+) current, (b) decrease of open probability and Ca (2+)/voltage sensitivity of single MaxiK channel, and (c) reduction of tamoxifen induced MaxiK activation."
24347614
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"In addition, like oestrogen, tamoxifen activates the BK channel in smooth muscle (Dick et al 2001) and a large conductance chloride channel in NIH3T3 fibroblast cells (Valverde et al 2002)."
14713365
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"Ethylbromide tamoxifen did not increase BK channel NP (o) in cell attached or inside-out patches; however, subsequent addition of equimolar tamoxifen did."
11961128
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"It has been shown that Tamoxifen, which is an agonist of estrogen receptors that is widely used for breast cancer therapy, also activates the BK channel, but is at least 10 times more potent than E2, causing a reversible and fast effect at concentrations as low as 0.1 muM."
25346693
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"The xenoestrogen, tamoxifen, and the endogenous steroid hormone 17beta-estradiol were also found to activate the BK channel in a beta1- dependent manner."
27238261
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"In addition, like oestrogen, tamoxifen activates the BK channel in smooth muscle (Dick et al 2001) and a large conductance chloride channel in NIH3T3 fibroblast cells (Valverde et al 2002)."
14713365